Renal toxicity with liposomal doxorubicin in metastatic breast cancer

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Kristyn E YemmLupe G Salazar

Abstract

There is no preferred treatment option for metastatic breast cancer; therefore, treatment should provide palliation, prolong survival, control symptoms, and improve quality of life. Liposomal doxorubicin formulations have been shown to have less alopecia, nausea, vomiting, and myelosuppression than traditional doxorubicin, but more skin toxicities and infusion reactions. Prolonged use of liposomal doxorubicin may be associated with unrecognized or less well-defined toxicities. We report a case of acute kidney injury and progressively worsening chronic kidney disease necessitating dialysis in a patient who received prolonged therapy with liposomal doxorubicin for treatment of metastatic breast cancer. This case report should give caution to providers considering prolonged use of liposomal doxorubicin in the metastatic breast cancer setting as we observed sustained renal toxicity, long past the cessation of treatment.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H JoensuuR Huovinen
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E R O'BrienUNKNOWN CAELYX Breast Cancer Study Group
Jan 6, 2010·Journal of Pediatric Hematology/oncology·Safa BarişTiraje Celkan
Oct 23, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H Roché, L T Vahdat
Dec 12, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nasreen MohamedRohan John
Feb 1, 2013·Kidney International·Kenar D JhaveriJai Radhakrishnan
Jul 22, 2014·Hemodialysis International·Pierre-Louis CarronJocelyne Maurizi Balzan
May 31, 2015·Clinical Breast Cancer·Eunpi ChoVijayakrishna K Gadi
Aug 19, 2015·BMC Medicine·Jesus AnampaJoseph A Sparano

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Citations

Feb 7, 2021·Basic & Clinical Pharmacology & Toxicology·Ali A Shati, Attalla F El-Kott
Jul 20, 2021·Frontiers in Cardiovascular Medicine·Gabriel Silva Marques BorgesSylvain Richard

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Methods Mentioned

BETA
biopsy

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