Renal toxicodynamics of ochratoxin A: a pathophysiological approach

Kidney & Blood Pressure Research
M Gekle, S Silbernagl

Abstract

Ochratoxin A (OTA) is a secondary fungal metabolite that has been detected in a variety of animal chows, human food and in up to 80% of human blood samples of several Western countries. Its main target is the kidney. OTA is the causing agent of Danish porcine nephropathy and increases the incidence of renal carcinomas and adenomas in rats. Pathophysiological studies revealed that OTA acts on different sites along the nephron. Acute OTA exposure leads to an impairment of postproximal nephron function, predominantly of the collecting duct, resulting in altered electrolyte and titratable acid excretion. The underlying mechanism is most probably a blockade of anion conductance in the plasma membrane at nanomolar concentrations of OTA with subsequent disturbance of cellular acid-base homeostasis as shown in cultured kidney cells. Disturbance of cellular pH homeostasis is probably also involved in OTA-induced transformation of cultured kidney cells. Chronic OTA exposure leads to an additional reduction in the urine concentrating ability. Renal hemodynamics and the secretory function of the proximal tubule are affected by OTA after prolonged but not by acute exposure. OTA increases resistance in the vas efferens with a subsequent decr...Continue Reading

Citations

Jan 5, 2005·Pflügers Archiv : European journal of physiology·Bonnie L Blazer-YostMichael Gekle
Jun 10, 2000·Journal of Veterinary Pharmacology and Therapeutics·E Petzinger, K Ziegler
Feb 3, 2004·Food Additives and Contaminants·S MacDonaldD Chan
Aug 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·Lada RumoraMaja Segvić Klarić
Oct 28, 2015·Toxins·Alexandra H Heussner, Lewis E H Bingle
Nov 26, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H MalekinejadN Mirzakhani
Jan 7, 2005·Molecular Nutrition & Food Research·Michael GekleGerald Schwerdt
Oct 17, 1998·Toxicology and Applied Pharmacology·M GekleH Schramek
Oct 19, 2002·Biochimica Et Biophysica Acta·G J SchaafJ Fink-Gremmels
Sep 27, 2012·Toxicology and Industrial Health·Mansour A Al-Hazmi
Jul 8, 2016·Toxins·Frantisek MalirJakub Toman
Aug 18, 2005·Journal of Agricultural and Food Chemistry·Alberto A E BertelliLuca Giovannini

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