Nov 26, 1977

Renal transplantation and B-cell cross-matches with autoantibodies and alloantibodies

Lancet
A Ting, P J Morris

Abstract

Of 51 cadaveric kidneys transplanted between June, 1976, and June, 1977, 18 were transplanted in the presence of a positive cross-match against the donor's B lymphocytes. 11 of these positive cross-matches were due to alloantibodies and 7 due to autoantibodies. Autoantibodies were defined not only on the basis of autoreactivity with B lymphocytes but also by their absent or restricted reactivity with lymphocytes from patients with chronic lymphocytic leukaemia. Transplants in 8 of 11 patients with a positive alloantibody-B-cell cross-match and in 6 of 7 patients with a positive autoantibody-B-cell cross-match were successful at 3 months. These success-rates were no different from those found in patients with a negative B-cell cross-match. Thus, renal allografts may be performed with a reasonable assurance of success in the presence of a positive B-cell cross-match whether due to autoantibodies or to alloantibodies.

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Mentioned in this Paper

Autoantibodies
T-Lymphocyte
Graft Survival
Cross Reactions
Kidney
B-Lymphocytes
Cadaver
HLA Typing
Transplantation, Homologous
Forssman Antibody

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