PMID: 7024498Oct 1, 1981Paper

Renal transplantation in children less than 2 years of age

The Journal of Pediatrics
D I Moel, K M Butt

Abstract

We report our experience with renal transplantation in ten infants receiving grafts at ages 1 to 21 months. All children were followed for at least six months posttransplantation, except two who died in the immediate postoperative period. Kidneys were obtained from cadaveric donors: four from anencephalic newborn infants and eight others from donors aged 9 months to 21 years at death. Immunosuppressive therapy consisted of prednisone, azathioprine, and antithymocyte globulin, with added doses of methylprednisolone for rejection. Patient survival at six months was 8/10, at two years 3/7 (three patients who were alive but were followed for less than two years are excluded), and at present 5/10. Graft survival at six months was 5/10, at two years 2/12, and at present 1/12. Cadaveric renal transplantation in small children is technically feasible, but the enormous time and effort involved in such an undertaking must be re-evaluated.

Citations

Feb 2, 1985·Lancet·P K DonnellyE Eastham
Sep 1, 1986·Annals of Surgery·J S NajarianS M Mauer
Sep 1, 1990·Annals of Surgery·J S NajarianT E Nevins
Nov 29, 2002·Archives of Disease in Childhood·M G Coulthard, J Crosier
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mirja WedekinLars Pape
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G S ArbusD Thompson
Jul 1, 1990·The Journal of Urology·J T RosenthalR N Fine
Mar 8, 1990·The New England Journal of Medicine·UNKNOWN Medical Task Force on Anencephaly
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T E Nevins
Apr 23, 1987·The New England Journal of Medicine·W HolzgreveK Köhler
Feb 27, 1997·Transplantation·G TydénJ Sandberg
Feb 10, 2010·Journal of Child Neurology·John R MytingerRobert S Rust
Oct 13, 2016·Pediatric Research·Priya S Verghese
Jul 1, 1989·Journal of Child Neurology·L P Ivan
Jul 1, 1988·Indian Journal of Pediatrics·D B Gradus, R N Fine
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C Cohen
Sep 1, 1984·The Journal of Urology·S OhshimaS Itoh
Jan 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·A HasegawaT Ohara
Aug 29, 2017·Transplantation·Blanche M ChaversSrinath Chinnakotla
Jan 1, 1992·European Journal of Pediatrics·T E Nevins
May 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T E BunchmanS M Mauer
Aug 11, 1992·Irish Journal of Medical Science·G ThomasD Gill
Jan 1, 1994·Acta Paediatrica·P CochatD Floret
Jan 9, 2004·Pediatric Clinics of North America·Mark R Benfield
Mar 1, 1995·Kidney International·W E Harmon
Sep 1, 1992·Kidney International·D M BriscoeW E Harmon

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