Renal transplantation in diabetic patients

Transplantation Proceedings
J BittarP U Massari

Abstract

Diabetes is one of the main causes of end-stage renal disease (ESRD) and admission to hemodialysis, and the demand for kidney transplantation in this population has increased. Our aim was to evaluate the clinical aspects and survival of diabetic patients with kidney transplants by comparing them with the nondiabetic population. Patients transplanted during the period from 1994 to 2003 were evaluated for this study. The transplant and demographic characteristics were analyzed by the chi-square test and Student t test according to the type of variable. Kaplan-Meier curves and the log-rank test were used to evaluate the graft and patient survival. From a total of 523 consecutive renal transplants, 35 (6.6%) were diabetics who were older than nondiabetics (47 +/- 11 years vs 37 +/- 16, P < .002). Patients received immunosuppression with cyclosporine (84.3%), tacrolimus (11.2%), azathioprine (46.6%), mycophenolate mofetil (43.5%), and steroids (all patients). The diabetic patients had a higher percentage of living donors (33.5% vs 17.2%; P = .04). Graft survival rates at 1, 3, and 5 years were 82.7%, 70.9%, and 63.0% in the diabetic patients and 87.6%, 79.0%, and 72.5% (P = .6) in the nondiabetic patients. Patient survival at 5 year...Continue Reading

References

Nov 1, 1995·Kidney International·M E Williams
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M M Hirschl
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E A Friedman
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Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert S GastonUNKNOWN National Kidney Foundation Task Force on Diabetes and Transplantation
Feb 4, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ralf SchielGünter Stein
Jul 15, 2005·Kidney International. Supplement·Ana Maria CusumanoUNKNOWN Latin American Registry of Dialysis and Renal Transplantation

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Citations

Oct 15, 2009·Diabetology & Metabolic Syndrome·Erika B RangelJosé O Medina-Pestana
Nov 26, 2010·International Urology and Nephrology·Vivek B KuteVeena R Shah
Nov 26, 2009·Ageing Research Reviews·Miaozong WuEric R Blough
Jun 13, 2009·Transplantation Reviews·Julio BittarPablo U Massari
Jul 10, 2013·Seminars in Dialysis·Phuong-Thu T PhamPhuong-Chi T Pham

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