Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome

BioMed Research International
Fengying WangZiqiang Zhu

Abstract

This study aimed to investigate the clinical significance of complement 3 (C3) deposition in renal tubules of children with primary nephrotic syndrome (PNS). The clinical and pathological characteristics of PNS were retrospectively reviewed in 99 PNS pediatric patients, who were divided into the C3 deposition and the non-C3 deposition groups. A total of 39 patients (39.39%) had renal tubule C3 deposition. In the C3 deposition group, the ratios of urine N-acetylglucosaminidase/creatinine (UNAG/Cr), urine β2 microglobulin/creatinine (Uβ2MG/Cr), and urine transferrin/creatinine (UTRF/Cr) were significantly higher than those of the non-C3 deposition group. The patients of the C3 deposition group had lower serum total protein and albumin, higher cholesterol and D-dimer (DD), lower proportion of CD3+CD8+ cells, and higher proportion of CD19+CD23+ cells. The number of the patients with interstitial fibrosis, renal cell vacuolar degeneration, renal tubular immunoglobulin deposition, and severe tubulointerstitial injury in the C3 deposition group was higher than that of the non-C3 deposition group. The C3 deposition intensity was positively correlated with the number of recurrences. PNS pediatric patients with C3 deposition in renal tub...Continue Reading

References

Apr 25, 2000·American Journal of Nephrology·H NakagawaR Kikkawa
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Mihaela GherghiceanuE Mandache
Apr 14, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kerstin BenzKerstin Amann
Jan 22, 2011·Contributions to Nephrology·Shao yu ZhangDjillali Sahali
Jun 17, 2011·Kidney International·Lihua BaoRichard J Quigg
Nov 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Om P MishraRajniti Prasad
Jan 11, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Beata Banaszak, Paweł Banaszak
Apr 30, 2013·Seminars in Thrombosis and Hemostasis·Biagio BarbanoRosario Cianci
Aug 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hassib ChehadeEric Girardin
Oct 15, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wagner de Fátima PereiraAna Cristina Simões e Silva
Dec 12, 2013·Journal of Clinical Immunology·Lu LiuGuolan Xing
Dec 18, 2013·Irish Journal of Medical Science·K Taranta-JanuszB Szynaka
Dec 19, 2013·Clinical and Experimental Nephrology·Deepti SuriSurjit Singh
Jan 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brad H Rovin, Samir V Parikh
Aug 17, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andrea PasiniUNKNOWN NefroKid Study Group
Aug 22, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshiko HibiKatsuaki Kasahara
Apr 19, 2015·Diagnostic Pathology·Ganesh Kumar ViswanathanKusum Joshi
Jun 25, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Yi-Miao ZhangMing-Hui Zhao
Jul 19, 2017·BMC Nephrology·Takayuki KatsunoShoichi Maruyama
Sep 15, 2017·Kidney Research and Clinical Practice·Ji Hyun KimHae Il Cheong
Sep 16, 2017·Paediatrics and International Child Health·Mallory L DownieDamien G Noone
Oct 1, 2017·Jornal de pediatria·Fábio Tadeu Lourenço GuimarãesAna Cristina Simões-E-Silva
Dec 6, 2017·Central-European Journal of Immunology·Katarzyna PopkoElżbieta Kuźma-Mroczkowska
Dec 13, 2017·Advances in Chronic Kidney Disease·Scott E Wenderfer, Joseph P Gaut

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Methods Mentioned

BETA
pharmacotherapy
biopsy
ELISA
flow cytometry
electron
electron microscopy
light microscopy

Software Mentioned

SPSS

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