PMID: 11322374Apr 27, 2001Paper

Renal tubular dysfunction in epileptic children on valproic acid therapy

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S AltunbaşakH R Burgut

Abstract

To investigate the effects of valproic acid (VPA) on renal tubular function, we examined 15 ambulatory children with epilepsy who received VPA for at least 6 months. None of the patients had mental retardation. Fourteen age- and sex-matched children were used as a control group. No statistically significant differences were found between patients and control subjects with respect to blood urea nitrogen (BUN), creatinine (Cr), uric acid, creatinine clearance (Ccr), tubular reabsorption of phosphorus (TRP), urinary Ca:creatinine ratio, urinary pH and mean urinary beta2-microglobulin concentrations (P>0.05). Protein and glucose in patient urine samples were negative. Urine microscopic examinations and amino acid chromatographies of patients were also normal. However, significant differences were found between patient and control groups with respect to mean urinary N-acetyl-beta-D-glucosamine:creatinine ratio (NAG:Cr) and mean urinary malondialdehyde:creatinine (MDA:Cr) ratio (P<0.05). In conclusion, ambulatory children with epilepsy taking VPA therapy may develop proximal renal tubular dysfunction. Although this finding is clini-cally insignificant, it should be kept in mind during VPA therapy.

Citations

Jan 23, 2002·Pharmacoepidemiology and Drug Safety
Mar 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Toru WatanabeTokinari Abe
Apr 26, 2011·Journal of General Internal Medicine·Sandeep M PatelMark L Wieland
Apr 12, 2003·Brain & Development·Hideto YoshikawaTokinari Abe
Nov 19, 2002·Pediatric Neurology·Emad L Zaki, James E Springate
Jun 5, 2007·Clinical Neuropharmacology·Achilleas AttilakosAnastasia Garoufi
Jun 6, 2012·BMJ Case Reports·Keith K Lau, Koyelle Papneja
Apr 18, 2009·Molecular Cancer Therapeutics·Madeleine S Q KortenhorstRobert W Veltri
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May 31, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mark Jonathan Knights, Eric Finlay
Oct 20, 2004·Critical Reviews in Microbiology·A Handan Dinçer, Taner Baysal
Oct 20, 2006·Renal Failure·M Ozlem HergünerRefik Burgut
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Mar 23, 2010·Pediatric Neurology·Ayumi EndoHideo Mugishima
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Jul 12, 2017·Expert Review of Clinical Pharmacology·Sherifa Ahmed Hamed
Jul 17, 2018·Expert Review of Clinical Pharmacology·Sherifa A HamedSuzan M Abou Elnour
Jan 29, 2010·Proceedings. Biological Sciences·Emanuel Azizi, Thomas J Roberts

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