Abstract
To clarify the mechanism by which renal potassium (K) excretion is reduced in children with insulin-dependent diabetes mellitus, we studied two groups of patients: (A) at diagnosis and (B) after at least 1 year of follow-up. Group A (15 children) was studied twice: on the day of admission and after 1 month of insulin therapy. On admission, urinary K excretion, fractional K excretion, and transtubular K concentration gradient (TTKG) were significantly decreased, but became normal after extended insulin therapy. TTKG was inversely correlated with blood glucose (P < 0.001) and hemoglobin A1c (HbA1c, P < 0.001). Group B (73 children with a mean follow-up of 54 +/- 36 months) was subdivided according to the TTKG: 30 patients had a low TTKG < 4.0 (median 3.2) and 43 patients had a normal TTKG > or = 4.0 (median 5.2). Patients had a low TTKG and those with a normal TTKG had an identical duration of follow-up and similar values for plasma renin activity, aldosterone concentration, calciuria, magnesiuria, albumin excretion rate, and creatinine clearance. However, those with a low TTKG had significantly higher blood HbA1c levels, urine volume, and glucosuria. Logistic regression analysis showed that the only independent variables predict...Continue Reading
References
Oct 1, 1978·Clinical Endocrinology·P RaskinC Y Pak
Feb 1, 1975·Diabetes·A R ChristliebT Suzuki
Jun 1, 1992·Diabetologia·R G Larkins, M E Dunlop
Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Sep 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M RiesD Gekle
Mar 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-SorianoA Vallo
Jan 1, 1989·Archives of Disease in Childhood·D M GibbT M Barratt
May 1, 1986·Medicine·H J AdroguéG Eknoyan
Nov 1, 1988·The Medical Clinics of North America·A E Kitabchi, M B Murphy
Jan 1, 1988·American Journal of Nephrology·M L WestM L Halperin
Feb 1, 1988·The American Journal of the Medical Sciences·S SmollerC A Vaamonde
Aug 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R S MartinJ P Hayslett
Oct 1, 1985·Archives of Disease in Childhood·M MiltényiA Szabó
Feb 13, 1986·The New England Journal of Medicine·V M MonnierR R Kohn
Mar 1, 1972·Medicine·A I Arieff, H J Carroll
Jan 1, 1968·British Journal of Industrial Medicine·G K Sluis-Cremer, R S Du Toit
Jun 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-Soriano
Dec 1, 1994·Kidney International·H HaK H Kim
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-Soriano, A Vallo
Jan 1, 1994·American Journal of Nephrology·M RoffiM G Bianchetti
Feb 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F GinevriR Gusmano
Mar 1, 1947·The Journal of Clinical Investigation·H E Martin, M Wertman
Citations
Dec 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anja Lehnhardt, Markus J Kemper
Jul 2, 2016·Kidney Research and Clinical Practice·Yuichiro UedaYoshiyuki Morishita
Feb 24, 2001·Diabetes Care·E Matteucci, O Giampietro
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh