Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation

Journal of the American Heart Association
Hiromichi WakuiSatoshi Umemura

Abstract

Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressure regulation in response to high salt (HS) loading, using ATRAP transgenic mice on a salt-sensitive C57BL/6J background. Renal ATRAP transgenic (rATRAP-Tg) mice, which exhibit renal tubule-dominant ATRAP enhancement, and their wild-type littermate C57BL/6J mice on a normal salt diet (0.3% NaCl) at baseline were subjected to dietary HS loading (4% NaCl) for 7 days. In rATRAP-Tg mice, the dietary HS loading-mediated blood pressure elevation was suppressed compared with wild-type mice, despite similar baseline blood pressure. Although renal angiotensin II level was comparable in rATRAP-Tg and wild-type mice with and without HS loading, urinary sodium excretion in response to HS loading was significantly enhanced in the rATRAP-Tg mice. In addition, functional transport activity of the amiloride-sensitive epithelial Na(+) channel was significantly decreased under saline volume-expanded conditions in rATRAP-Tg mice compared with wild-type mice, witho...Continue Reading

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Citations

Jul 29, 2017·Journal of the American Heart Association·Kazushi UnedaKouichi Tamura
May 31, 2018·American Journal of Physiology. Renal Physiology·Ashfaq AhmadJoseph K Ritter
Apr 19, 2019·Scientific Reports·Kengo AzushimaKouichi Tamura
Oct 14, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kouichi TamuraTakahiro Yamaji

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