PMID: 6966255Jan 1, 1980Paper

Renal vascular reactivity in the young spontaneously hypertensive rat

Hypertension
M G CollisP M Vanhoutte

Abstract

The renal resistance vessels of the mature spontaneously hypertensive rat (SHR) exhibit increased reactivity to vasoconstrictor agonists. This could be a cause or consequence of hypertension. We have compared vascular reactivity in isolated perfused kidneys from 46-day-old SHR and from normotensive control rats. The amplitude of responses in kidneys from the SHR to angiotensin II, barium chloride, or norepinephrine was not different from the control. Therefore, increased reactivity of the renal vascular smooth muscle cannot be an early pathogenic mechanism in spontaneous hypertension. Responses evoked by 5-hydroxytryptamine (serotonin) were of a greater amplitude in the SHR than in the control kidney. However, this difference was due to an interaction of serotonin with the sympathetic nerves, as it was abolished by treatment of the rats with 6-hydroxydopamine. Responses induced by electrical stimulation of the renal sympathetic nerves were also of greater amplitude in SHR than in control kidneys, both before and after the blockade of norepinephrine disposition mechanisms. Nerve stimulation evoked a greater efflux of endogenous norepinephrine from kidneys of the SHR than from those of control rats. Thus, the increased reactivity...Continue Reading

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Citations

May 29, 2012·Current Hypertension Reports·Francine Z Marques, Brian J Morris
Apr 8, 1982·European Journal of Pharmacology·C RicherJ F Giudicelli
Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas
Oct 8, 1999·Journal of Cardiovascular Pharmacology·M M El-Mas, A A Abdel-Rahman
Jan 1, 1983·American Journal of Public Health·M J Mallick
Oct 31, 1998·Journal of Hypertension·A Sánchez-MendozaB Escalante
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·P Weidmann
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T T ZsotérS Sirko
May 31, 1984·The American Journal of Medicine·P Sleight
Dec 31, 1993·International Journal of Cardiology·M Chandra, N Chandra
Jun 1, 1988·Hypertension·R J Roman, M L Kaldunski
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGillC J Schwartz
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·F M Abboud
Jul 18, 2001·American Journal of Physiology. Renal Physiology·M Salomonsson, W J Arendshorst
Jan 1, 1990·Annals of the New York Academy of Sciences·K R Borkowski
Oct 12, 1999·The American Journal of Physiology·T NagayamaS Satoh

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