Renal vascular responsiveness to arachidonic acid in experimental diabetes

British Journal of Pharmacology
John Quilley, J C McGiff

Abstract

1. Isolated perfused kidneys from diabetic rats (duration 4-6 and 20-24 weeks) were more sensitive to the vasoconstrictor effects of arachidonic acid than kidneys from age-matched control rats. Sensitivity diminished with age in both control and diabetic groups. 2. The enhanced vasoconstrictor effect of arachidonic acid in diabetic rat kidneys was associated with increased conversion to prostaglandins. 3. The renal vasoconstrictor response to arachidonic acid in both groups was reduced by thromboxane A2/prostaglandin H2 receptor antagonism but not by inhibition of thromboxane synthase. 4. Diabetic rat kidneys were also more sensitive to the vasoconstrictor effects of the endoperoxide analogue, U46619, while vasoconstrictor responses to phenylephrine were not markedly different from those of control rat kidneys. 5. In conclusion, prostaglandin endoperoxides appear to mediate arachidonic acid-induced vasoconstriction in diabetic and control rat kidneys. The enhanced renal vasoconstrictor response to arachidonic acid in diabetic rats results from increased sensitivity to endoperoxides and increased formation of endoperoxides from arachidonic acid.

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Citations

Aug 26, 1999·Diabetes Research and Clinical Practice·W G MayhanG M Sharpe
Aug 31, 1999·Journal of Autonomic Pharmacology·V M GarcíaM M Elías
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology·W C HodgsonR G King
Jun 21, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mohamad SebaiRobert L Hester
Jan 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Benjamin L HodnettRobert L Hester
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F R DeRubertis, P A Craven
Jun 7, 2006·European Journal of Pharmacology·Yu-Jung ChenJohn Quilley
Sep 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lusha XiangRobert L Hester
May 10, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jing LiJohn Quilley
Feb 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Lusha XiangRobert L Hester
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Yu-Jung ChenJohn Quilley

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