Renal vasoconstriction during inhibition of NO synthase: effects of dietary salt

Kidney International
X DengC S Wilcox

Abstract

Since dietary salt loading enhances nitric oxide (NO) generation in the kidney, we investigated the hypothesis that changes in salt intake have specific effects on vascular resistance in the kidney mediated by the L-arginine-NO pathway. We contrasted changes in renal and hindquarter vascular resistances (RVR and HQVR) in anesthetized rats during intravenous infusions of graded doses of the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). Groups (N = 8 to 10) of rats were maintained on a high salt (HS) or low salt (LS) diet for two weeks. Compared to those on LS, rats on HS had a greater increase in mean arterial pressure (delta MAP; +32 +/- 4 vs. +22 +/- 3%; P = 0.05) and RVR (+160 +/- 17 vs. +83 +/- 10%; P < 0.005) and a greater fall in renal blood flow (delta RBF; -47 +/- 3 vs. -32 +/- 4%; P < 0.01); changes in HQVR were similar in the two groups. The enhanced RVR response to L-NAME in HS rats could not be ascribed to the higher renal perfusion pressure (RPP) since it persisted in rats whose RPP was controlled by adjustment of a suprarenal aortic clamp. Changes in RVR with an NO donor (SIN-1) were similar in HS and LS rats. L-NAME reduced plasma renin activity in both HS and LS rats. After inhibition of ACE wi...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Nov 1, 1992·Hypertension·D H SigmonW H Beierwaltes
Dec 1, 1992·Journal of the American Society of Nephrology : JASN·D H SigmonW H Beierwaltes
Jun 1, 1992·Hypertension·J D Imig, R J Roman
Nov 1, 1991·The Journal of Clinical Investigation·P Y Chen, P W Sanders
Dec 1, 1991·Kidney International·C S WilcoxH Snellen
Oct 1, 1989·Statistics in Medicine·L Kaiser
Jan 1, 1989·British Journal of Clinical Pharmacology·P M VanhoutteM J Vidal
Feb 1, 1993·The Journal of Clinical Investigation·P J Shultz, J P Tolins
Oct 1, 1993·Journal of the American Society of Nephrology : JASN·T TakenakaL G Navar

❮ Previous
Next ❯

Citations

Feb 28, 2002·European Journal of Pharmacology·Run-Xian TianYouichi Abe
Dec 19, 1996·European Journal of Pharmacology·A ZappelliniG De Nucci
Oct 7, 2000·Clinical and Experimental Pharmacology & Physiology·K TsuchiyaH Nihei
Sep 15, 1998·Kidney International. Supplement·C S Wilcox, W J Welch
Nov 23, 2010·Current Opinion in Nephrology and Hypertension·Mehmet KanbayPaul W Sanders
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·W J Welch, C S Wilcox
Jan 1, 1995·Fundamental & Clinical Pharmacology·I A Reid, Y J Chiu
May 20, 2004·Kidney International·Michael ObstFriedrich C Luft
Jul 27, 2006·Acta Physiologica·P F Mount, D A Power
Apr 3, 2009·American Journal of Physiology. Renal Physiology·Paul W Sanders
Dec 18, 1998·Hypertension·R Zatz, C Baylis
Oct 28, 1998·The Journal of Clinical Investigation·C WagnerA Kurtz
Apr 2, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshio KonishiMasahito Imanishi
Nov 26, 1999·Clinical and Experimental Hypertension : CHE·M S ZhouH Kosaka
Oct 8, 1999·Clinical and Experimental Hypertension : CHE·Y J ChiuI A Reid
Feb 14, 1998·Kidney International·R C Blantz
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J SchmidtC Baylis
Jan 9, 1998·The Journal of Laboratory and Clinical Medicine·J C PassmoreD A McCarron
Jun 19, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick K K LeongAlicia A McDonough
Aug 18, 2001·Circulation Research·W Z YingP W Sanders
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jürgen SchnermannJosie P Briggs
Aug 1, 1995·Hypertension·X DengC S Wilcox
Mar 1, 1996·Hypertension·D L Mattson, D J Higgins
Mar 5, 2002·Journal of Hypertension·Norberto Perico, Giuseppe Remuzzi
Jun 5, 1998·The American Journal of Physiology·J N BechE B Pedersen
Nov 16, 2002·Journal of Applied Physiology·Christian K RobertsR James Barnard
Oct 9, 2015·American Journal of Physiology. Renal Physiology·Wenguang FengPaul W Sanders
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner
Oct 12, 1999·The American Journal of Physiology·W Z Ying, P W Sanders
Apr 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charlotte Mehlin SorensenNiels-Henrik Holstein-Rathlou
Oct 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Fredrik PalmChristopher S Wilcox
Jun 25, 1998·The American Journal of Physiology·C S WilcoxW J Welch
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C KitiyakaraC S Wilcox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.