Renal vasoconstrictor response to 5-hydroxytryptamine in the in situ autoperfused rat kidney: involvement of angiotensin II and the 5-HT2 receptor activation

European Journal of Pharmacology
Asunción MoránL San Román

Abstract

Using a number of agonist and antagonist compounds, we attempted to characterize the responses and receptors involved in the effects of 5-hydroxytryptamine (5-HT) in the in situ autoperfused rat kidney. An intra-arterial (i.a.) bolus injection of 5-HT (0.0125 to 0.1 microg/kg) increased renal perfusion pressure in a dose-dependent way but did not change the systemic blood pressure. The 5-HT2 receptor agonist, (1-(3-chlorophenyl) piperazine), m-CPP, caused a local vasoconstrictor effect in the autoperfused rat kidney. An intra-arterial injection of 5-carboxamidotryptamine, 5-CT and 1-(m-chlorophenyl)-biguanide (m-CPBG) did not modify the renal perfusion pressure. The vasoconstrictor effect elicited by 5-HT and m-CPP was significantly decreased by ritanserin, enalapril and losartan but was not modified by prazosin, propranolol or indomethacin pretreatment. Our data suggest that the vasoconstrictor serotonergic response induced in the in situ autoperfused rat kidney is mediated through angiotensin II activation by a local 5-HT2 receptor mechanism.

References

Dec 1, 1991·British Journal of Pharmacology·S TadipatriP R Saxena
Jan 1, 1990·Journal of Cardiovascular Pharmacology·M H ZinkR H Alper
Jan 1, 1991·Journal of Cardiovascular Pharmacology·J L BlackshearN K Hollenberg
Feb 14, 1991·European Journal of Pharmacology·T TakahashiS Satoh
Nov 1, 1990·Kidney International·N H LameireM A Waterloos
May 1, 1989·The American Journal of the Medical Sciences·X R DingH D Itskovitz
Sep 1, 1986·Kidney International·J L BlackshearN K Hollenberg
Jan 1, 1981·The Journal of Physiology·J G GerberR D Olsen
Jun 1, 1993·Trends in Pharmacological Sciences·P P HumphreyD Hoyer
Feb 1, 1993·Kidney International·K EndlichM Steinhausen

Citations

Jan 31, 2004·European Journal of Pharmacology·Andrew J TaylorGarry Jennings
Feb 28, 2002·European Journal of Pharmacology·Run-Xian TianYouichi Abe
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Wei Ni, Stephanie W Watts
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·E CalamaL San Román
Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
May 25, 2015·Vascular Pharmacology·José-Ángel García-PedrazaAsunción Morán
Jun 10, 2016·Renal Failure·Acelya ErikciSamiye Yabanoglu-Ciftci
Aug 5, 2017·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
Jan 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Stephanie W Watts, Janice M Thompson
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaAsunción Morán

Related Concepts

Angiotensin I
Angiotensin II, Val(5)-
Metazoa
Electric Stimulation Technique
Kidney
Perfusion
Receptors, Tryptamine
Hydroxytryptamine
Serotonin Antagonists
Vascular Constriction (Function)

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