Renal vasoconstrictor response to 5-hydroxytryptamine in the in situ autoperfused rat kidney: involvement of angiotensin II and the 5-HT2 receptor activation

European Journal of Pharmacology
Asunción MoránL San Román


Using a number of agonist and antagonist compounds, we attempted to characterize the responses and receptors involved in the effects of 5-hydroxytryptamine (5-HT) in the in situ autoperfused rat kidney. An intra-arterial (i.a.) bolus injection of 5-HT (0.0125 to 0.1 microg/kg) increased renal perfusion pressure in a dose-dependent way but did not change the systemic blood pressure. The 5-HT2 receptor agonist, (1-(3-chlorophenyl) piperazine), m-CPP, caused a local vasoconstrictor effect in the autoperfused rat kidney. An intra-arterial injection of 5-carboxamidotryptamine, 5-CT and 1-(m-chlorophenyl)-biguanide (m-CPBG) did not modify the renal perfusion pressure. The vasoconstrictor effect elicited by 5-HT and m-CPP was significantly decreased by ritanserin, enalapril and losartan but was not modified by prazosin, propranolol or indomethacin pretreatment. Our data suggest that the vasoconstrictor serotonergic response induced in the in situ autoperfused rat kidney is mediated through angiotensin II activation by a local 5-HT2 receptor mechanism.


Dec 1, 1991·British Journal of Pharmacology·S TadipatriP R Saxena
Jan 1, 1990·Journal of Cardiovascular Pharmacology·M H ZinkR H Alper
Jan 1, 1991·Journal of Cardiovascular Pharmacology·J L BlackshearN K Hollenberg
Feb 14, 1991·European Journal of Pharmacology·T TakahashiS Satoh
Nov 1, 1990·Kidney International·N H LameireM A Waterloos
May 1, 1989·The American Journal of the Medical Sciences·X R DingH D Itskovitz
Sep 1, 1986·Kidney International·J L BlackshearN K Hollenberg
Jan 1, 1981·The Journal of Physiology·J G GerberR D Olsen
Jun 1, 1993·Trends in Pharmacological Sciences·P P HumphreyD Hoyer
Feb 1, 1993·Kidney International·K EndlichM Steinhausen


Jan 31, 2004·European Journal of Pharmacology·Andrew J TaylorGarry Jennings
Feb 28, 2002·European Journal of Pharmacology·Run-Xian TianYouichi Abe
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Wei Ni, Stephanie W Watts
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·E CalamaL San Román
Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
May 25, 2015·Vascular Pharmacology·José-Ángel García-PedrazaAsunción Morán
Jun 10, 2016·Renal Failure·Acelya ErikciSamiye Yabanoglu-Ciftci
Aug 5, 2017·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
Jan 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Stephanie W Watts, Janice M Thompson
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaAsunción Morán

Related Concepts

Angiotensin I
Angiotensin II, Val(5)-
Electric Stimulation Technique
Receptors, Tryptamine
Serotonin Antagonists
Vascular Constriction (Function)

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.