Renal vein thrombosis in a newborn with prothrombotic genetic risk factors

Journal of Perinatal Medicine
P GiordanoA Iolascon

Abstract

Environmental and genetic risk factors interact to cause venous thromboembolism. Renal vein thrombosis in the newborn has been frequently associated with "risk factors" as catheters, surgery or trauma, but it has also been demonstrated a pathogenetic role of genetic prothrombotic risk factors, i.e. activated protein C resistance and FV Leiden. The treatment of neonatal venous thrombosis varies worldwide and different approaches have been proposed. We present a case of renal vein thrombosis in a female newborn with normal plasma levels of protein C, protein S and antithrombin III, but with her genotype characterized by the presence of three prothrombotic risk factors: factor V Leiden, methylentetrahydrofolate reductase and platelet glycoprotein IIIa polymorphisms. The treatment with recombinant tissue plasminogen determined complete thrombus dissolution.

References

Feb 1, 1991·Anaesthesia and Intensive Care·B J AndersonN D Johnson

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Citations

Nov 16, 2007·Cardiovascular and Interventional Radiology·Jawad U KhanHyun S Kim
Dec 29, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Willem ProesmansChris Van Geet
Sep 12, 2006·Obstetrics and Gynecology Clinics of North America·Gili Kenet, Ulrike Nowak-Göttl
Jun 24, 2005·The Journal of Pediatrics·Stephen D MarksVibhuti S Shah
Jun 23, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Samar A MuwakkitMiguel R Abboud
Apr 18, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maria Rosaria RaspolliniDrucilla J Roberts
Nov 3, 2007·Pediatrics·Keith K LauUNKNOWN Canadian Pediatric Thrombosis and Hemostasis Network

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