Renal Volume in ADPKD Patient Evaluation

International Journal of Nephrology
M GallianiA Paone

Abstract

The clinical manifestations of ADPKD are related to the growth of renal cysts. Renal volume has been recognised as the biomarker that is able to identify those patients at risk of complications (hypertension and haematuria) and at risk of progression to End Stage Renal Disease (ESRD). Recently, several scores have been introduced to predict the evolution of ADPKD. The Mayo Clinic Group developed a classification based on renal volume as measured by CT or MRI and corrected for age and height (Ht-TKV); this allowed predicting the evolution of the disease, but it has not been fully validated so far. In addition, it is used to identify patients labelled as "fast progressors" and eligible for Tolvaptan therapy according to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) recommendations. We studied 80 patients who underwent MRI and had been classified as ADPKD typical form (class 1A-1E). A significant correlation between renal volume, hypertension, and low GFR was found (p < 0.005). A progressive increase in disease severity has been found across the different Mayo classes; 41.2% were eligible for Tolvaptan therapy. The results demonstrate that the Mayo method is easy to perform and provides val...Continue Reading

References

Mar 1, 1983·Kidney International·K A Franz, F C Reubi
May 19, 2006·The New England Journal of Medicine·Jared J GranthamUNKNOWN CRISP Investigators
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jared J GranthamVicente E Torres
Apr 24, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Esther MeijerRon T Gansevoort
Jun 12, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Krista L LentineMark A Schnitzler
Feb 22, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Arlene B ChapmanJared J Grantham
Jun 7, 2014·Journal of the American Society of Nephrology : JASN·María V IrazabalUNKNOWN CRISP Investigators
Jul 8, 2015·Journal of the American Society of Nephrology : JASN·Emilie Cornec-Le GallYannick Le Meur
Nov 5, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fouad T Chebib, Vicente E Torres
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ron T GansevoortWim Van Biesen
Jan 9, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN EAF co-chairsUNKNOWN Roundtable participants

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Citations

Mar 12, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fouad T Chebib, Vicente E Torres

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