Renalase attenuates mitochondrial fission in cisplatin-induced acute kidney injury via modulating sirtuin-3

Life Sciences
Zhimin HuangChangying Xing

Abstract

Acute kidney injury (AKI) can limit the clinical use of cisplatin in cancer treatment. The drivers of cisplatin-induced AKI include oxidative stress, mitochondrial dysfunction and apoptosis. Previous studies showed renalase protected cultured human renal proximal tubular cell (HK-2) against cisplatin induced necrosis, and renalase-knockout mice subjected to cisplatin showed exacerbated kidney injury. Therefore, it is necessary to determine the exact mechanisms of renalase in cisplatin-induced nephrotoxicity. To study the protective effect of renalase on cell viability, renal function, apoptosis, reactive oxygen species (ROS) production and mitochondrial dynamics, cultured HK-2 cells and male mice were subjected to cisplatin. Signaling proteins related to apoptosis, survival, and mitochondrial fission were analyzed by Western blot. In this study, we showed that the protective effect of recombinant renalase in cisplatin-induced AKI was associated with the regulation of ROS production, mitochondrial dynamics and sirtuin-3 (Sirt3) levels in vivo and in vitro. After cisplatin treatment, recombinant renalase restored Sirt3 expression, reduced mitochondrial fission and ROS generation. In HK-2 cells, downregulation of endogenous Sirt3 ...Continue Reading

References

Apr 10, 2003·American Journal of Physiology. Renal Physiology·Kazuhiko TsuruyaMitsuo Iida
Apr 21, 2005·The Journal of Clinical Investigation·Jianchao XuGary V Desir
Jun 14, 2005·The Journal of Pharmacology and Experimental Therapeutics·D Thomas DickeyEdward A Neuwelt
Mar 17, 2007·Annual Review of Biochemistry·Suzanne HoppinsJodi Nunnari
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·G M CereghettiL Scorrano
Apr 8, 2009·The Journal of Clinical Investigation·Craig BrooksZheng Dong
Jun 11, 2011·Molecular Cell·Eric L Bell, Leonard Guarente
May 3, 2013·Kidney International·Andrew J P LewingtonRavindra L Mehta
Dec 18, 2013·Molecular and Cellular Biology·Sadhana A SamantMahesh P Gupta
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Ling WangGary V Desir
Jun 20, 2014·American Journal of Physiology. Renal Physiology·Malvika H SolankiChristine N Metz
Sep 10, 2014·International Journal of Molecular Sciences·Shu-Hui DaiXiao-Fan Jiang
Jan 22, 2015·The Journal of Clinical Investigation·Marina MorigiAriela Benigni
Apr 24, 2015·PloS One·Ling WangGary V Desir
Jul 4, 2015·Trends in Endocrinology and Metabolism : TEM·Eoin McDonnellMatthew D Hirschey
Jan 31, 2016·Journal of the American Society of Nephrology : JASN·Bernard A AyangaFarhad R Danesh
Mar 1, 2016·Journal of Cellular and Molecular Medicine·Jianyong YinNiansong Wang
Feb 27, 2017·Journal of Cellular and Molecular Medicine·Yang WangGary V Desir
Apr 28, 2017·International Journal of Molecular Sciences·Yiru WuWenhu Liu
Feb 25, 2018·International Urology and Nephrology·Yiru WuWenhu Liu

❮ Previous
Next ❯

Citations

Jun 23, 2019·International Journal of Molecular Sciences·Sara J HolditchCharles L Edelstein
Apr 14, 2020·Journal of Cellular and Molecular Medicine·Ming LiTan-Qi Lou
Aug 3, 2020·Physiological Reports·Katsuyuki TokinoyaKazuhiro Takekoshi
Nov 25, 2020·Current Opinion in Nephrology and Hypertension·Wanning WangLu Cai
Sep 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chengni JinXiaoli Peng
Feb 14, 2021·Journal of Clinical Medicine·Magda WisniewskaAndrzej Pawlik
Jul 3, 2021·International Journal of Environmental Research and Public Health·Magda WiśniewskaAndrzej Pawlik
Jun 15, 2021·Oxidative Medicine and Cellular Longevity·Chunmei ZhangPeili Bu
Jun 20, 2021·Journal of Pharmaceutical and Biomedical Analysis·Zi-Meng ZhouFei Li
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qingqing LiXiaobin Zhong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.