Renalase contributes to protection against renal fibrosis via inhibiting oxidative stress in rats

International Urology and Nephrology
Yiru WuWen-Hu Liu

Abstract

Renal interstitial fibrosis (RIF) is a common pathway for progression of chronic kidney disease (CKD) to end-stage renal disease. In our previous study, it has been provided that renalase can ameliorate renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats. The other mechanism of renalase to alleviate renal fibrosis should be explored. In this study, we evaluated the role of oxidative stress in UUO rats and epithelial-mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells and examined the association of renalase. Oxidative stress could induce EMT and fibrosis in HK-2 cells. In the UUO model, oxidative stress occurred and maintained at a high level leading to RIF. Administration of renalase by adenovirus significantly attenuated oxidative stress and further in vitro study showed that renalase can exert anti-fibrosis by inhibiting oxidative stress. Our results prompt another mechanism of anti-fibrotic renal protection of renalase, which may be partly associated with inhibiting oxidative stress. These data provided another theoretical basis that supplementation with exogenous renalase may be a promising strategy for slowing or halting the progression of CKD.

References

Dec 2, 2000·The American Journal of Medicine·K A Nath, S M Norby
Apr 16, 2003·Kidney International. Supplement·Véronique Witko-SarsatBéatrice Descamps-Latscha
Nov 18, 2005·Journal of the American Society of Nephrology : JASN·Masaomi Nangaku
Feb 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ivica GrgicBenjamin D Humphreys
Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Alton B Farris, Robert B Colvin
May 10, 2012·The Journal of Pathology·Marco PrunottoSolange Moll
Aug 25, 2012·Nature Reviews. Cancer·Karen Block, Yves Gorin
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Ling WangGary V Desir
Dec 18, 2014·Current Vascular Pharmacology·Jolanta MalyszkoJacek S Malyszko
Jan 30, 2015·Clinical Science·Chet E HoltermanChris R J Kennedy
Apr 9, 2015·Frontiers in Physiology·Xiao-Ming MengHui Yao Lan
Apr 24, 2015·PloS One·Ling WangGary V Desir
Oct 9, 2015·Redox Biology·Daryl M Okamura, Subramaniam Pennathur
Mar 1, 2016·Journal of Cellular and Molecular Medicine·Jianyong YinNiansong Wang
Nov 4, 2016·International Journal of Molecular Sciences·Keiko Hosohata
Feb 6, 2017·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Ebru Gok OguzM Deniz Ayli
Feb 27, 2017·Journal of Cellular and Molecular Medicine·Yang WangGary V Desir
Apr 28, 2017·International Journal of Molecular Sciences·Yiru WuWenhu Liu
Jun 24, 2017·Pharmacology & Therapeutics·Charalampos MamoulakisAristides Tsatsakis
Sep 12, 2017·Kidney International·Liyu HeZheng Dong
Sep 29, 2017·Annals of Agricultural and Environmental Medicine : AAEM·Marcin DziedzicMałgorzata Goździewska
Sep 29, 2017·Cardiovascular Drugs and Therapy·Corey MageeDerek P Brazil

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Citations

Feb 14, 2020·FEBS Open Bio·Katsuyuki TokinoyaKazuhiro Takekoshi
Apr 30, 2020·International Reviews of Immunology·Alex ShneiderAnna Vakhrusheva
Aug 3, 2020·Physiological Reports·Katsuyuki TokinoyaKazuhiro Takekoshi
Feb 14, 2021·Journal of Clinical Medicine·Magda WisniewskaAndrzej Pawlik
Jan 19, 2021·Oxidative Medicine and Cellular Longevity·Iwona KwiatkowskaDariusz Pawlak
Oct 17, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jiawei LvShijian Quan
Feb 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruimei ZhouWei-Bing Xie
Jun 28, 2021·Free Radical Biology & Medicine·Alexis Paulina Jiménez-UribeJosé Pedraza-Chaverri

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