Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α

Journal of Cellular and Molecular Medicine
Feng WangNiansong Wang

Abstract

Ischaemic preconditioning (IPC) attenuates acute kidney injury (AKI) from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Here, it has been suggested that the renoprotective effect of renal IPC is partly mediated by renalase. In a model of brief intermittent renal IPC, the increased cortex renalase expression was found to last for 48 hrs. IPC significantly reduced renal tubular inflammation, necrosis and oxidative stress following renal ischaemia reperfusion injury. Such effects were attenuated by blocking renalase with an anti-renalase monoclonal antibody. We further demonstrated that renalase expression was up-regulated by hypoxia in vitro via an hypoxia-inducible factor (HIF)-1α mechanism. The IPC-induced up-regulation of renalase in vivo was also reduced by pre-treatment with an HIF-1α inhibitor, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole. In summary, the renoprotective effect of IPC is partly dependent on the renalase expression, which may be triggered by hypoxia via an HIF-1α mechanism. Endogenous renalase shows potential as a therapeutic agent for the prevention and trea...Continue Reading

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Citations

Apr 28, 2017·International Journal of Molecular Sciences·Yiru WuWenhu Liu
Feb 27, 2017·Journal of Cellular and Molecular Medicine·Yang WangGary V Desir
Feb 25, 2018·International Urology and Nephrology·Yiru WuWenhu Liu
Jun 2, 2017·American Journal of Physiology. Renal Physiology·George J Dugbartey, Andrew N Redington
Apr 21, 2017·Clinical Science·Zeyuan LuMingyu Liang
Jan 4, 2020·Clinical Science·Jianyong YinFeng Wang
Jul 22, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chang Sik PakHyo Jin Kang
Mar 1, 2016·Journal of Cellular and Molecular Medicine·Jianyong YinNiansong Wang
Feb 14, 2018·Molecular Medicine Reports·Jianjun HuangXiaolei Ye
Sep 6, 2020·Life Sciences·Fangfei ZhangFeng Wang
Aug 22, 2021·The Journal of Thoracic and Cardiovascular Surgery·Ari A Mennander

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Methods Mentioned

BETA
light microscopy
immunoprecipitation
pullout
PCR
antisense oligonucleotides
MDA
ChIP

Software Mentioned

Image Lab

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