Renalase, stroke, and hypertension in hemodialyzed patients

Renal Failure
Jolanta MalyszkoMichal Mysliwiec

Abstract

Hypertension and kidney disease have been associated with increased incidence of stroke. Renalase, a newly discovered hormone, is secreted by the kidney and circulates in blood. The aim of this study was to assess possible correlations between renalase, blood pressure, stroke, and cardiovascular status in prevalent hemodialyzed patients. Renalase was assessed using commercially available assay. Echocardiography was performed in each patient. Serum renalase was significantly lower in patients with a history of stroke (21%) than in patients without it. Similarly, renalase was significantly lower in hypertensive patients (82%) when compared with normotensives. Serum renalase correlated with creatinine, residual renal function, and transferrin saturation. The only predictor of renalase in multiple regression analysis was the presence of hypertension explaining 90% of the renalase variations. Our preliminary results suggest that renalase, probably due to the sympathetic nervous system hyperactivity, could be associated with hypertension and cardiovascular complications, including stroke in hemodialyzed patients. However, further studies are needed to establish the possible role of renalase in these complications. Renalase is "a new ...Continue Reading

References

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Citations

Oct 12, 2012·PloS One·Feng WangNiansong Wang
Oct 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gary V Desir, Aldo J Peixoto
Apr 26, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaogang LiWeihong Jiang
Nov 25, 2014·Seminars in Nephrology·Vito M Campese
Oct 31, 2012·Journal of the American Society of Hypertension : JASH·Gary V DesirAldo J Peixoto
Mar 1, 2016·Journal of Cellular and Molecular Medicine·Jianyong YinNiansong Wang
Dec 3, 2014·Advances in Medical Sciences·Jolanta MalyszkoSlawomir Dobrzycki
Apr 24, 2015·PloS One·Ling WangGary V Desir
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Ling WangGary V Desir
Sep 13, 2012·Angiology·Jolanta MalyszkoMaciej Banach
Jul 6, 2014·Current Opinion in Nephrology and Hypertension·Xiaojia GuoGary V Desir
Jul 3, 2021·International Journal of Environmental Research and Public Health·Magda WiśniewskaAndrzej Pawlik

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