Renaming NAFLD to MAFLD: Could the LDE System Assist in This Transition?

Journal of Clinical Medicine
Amedeo Lonardo

Abstract

Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (nonalcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition. The pitfalls of NAFLD diagnosis, together with disappointing results in therapeutic trials, and the inconsistencies and risks inherent in a "negative" definition (such as "nonalcoholic") as opposed to a "positive" one (i.e., "metabolic") are predicted to facilitate the proposed renaming of NAFLD to MAFLD. However, a premature change of terminology would not necessarily address major unmet needs in this area, and may even become counterproductive. As an aid to selecting more homogeneous cohorts of patients, I propose the LDE (Liver, Determinants, Extra-hepatic) classification system which, in principle, may help to assess the natural course of disease as well as the efficacy of novel drugs in patients with NAFLD/MAFLD.

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Citations

Apr 9, 2021·Advances in Therapy·Amedeo LonardoMarco Arrese
May 13, 2021·Trends in Endocrinology and Metabolism : TEM·Soo LimGiovanni Targher
Dec 11, 2021·European Journal of Clinical Investigation·Emilio Molina-MolinaVilma A Sardão

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Methods Mentioned

BETA
imaging techniques
biopsy
imaging

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