Rendering protein-based particles transiently insoluble for therapeutic applications.

Journal of the American Chemical Society
Jing XuJoseph M Desimone

Abstract

Herein, we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.

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Citations

Jul 16, 2013·Journal of the American Chemical Society·Jianwei ChenJin Wang
Feb 25, 2014·Chemico-biological Interactions·Bigyan R JaliJubaraj B Baruah
Dec 30, 2014·Advanced Drug Delivery Reviews·Qun WangRobert Langer
Mar 26, 2016·Molecular Pharmaceutics·Tojan B RahhalJoseph M DeSimone
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Anton BeletskiiFrank Malinoski
Oct 12, 2016·ACS Central Science·Joseph M DeSimoneCrista L Farrell
Jul 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph M DeSimone
Mar 14, 2017·Journal of the American Chemical Society·Tomoya SumaFrank Caruso
Jul 7, 2015·Biomaterials Science·John-Michael WillifordHai-Quan Mao
Jul 10, 2018·Nature Biotechnology·Li TangDarrell J Irvine
Sep 5, 2018·Chembiochem : a European Journal of Chemical Biology·Alejandro Méndez-ArdoyJavier Montenegro
Apr 16, 2019·Chemical Communications : Chem Comm·Qiao TangMing Wang
Nov 23, 2019·Macromolecular Rapid Communications·Zhengyu DengShiyong Liu
Dec 10, 2019·Expert Opinion on Drug Delivery·Nivedita ShettyQi Tony Zhou
May 15, 2013·Angewandte Chemie·Jing XuJoseph M DeSimone
Mar 8, 2016·Advanced Healthcare Materials·Akira IshiwatariTeruyuki Nagamune
Aug 25, 2018·Pharmaceutical Research·Erin M WilsonJoseph M DeSimone
Jan 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bing XueEugenia Kharlampieva
Feb 12, 2013·Chemical Communications : Chem Comm·Wentan WangYi Cheng
Jun 19, 2013·ACS Macro Letters·Stuart S DunnJoseph M Desimone
Aug 9, 2013·Molecular Pharmaceutics·Jing XuJoseph M DeSimone
Dec 19, 2013·Journal of the American Chemical Society·Antons SizovsJin Wang
Mar 26, 2013·Molecular Pharmaceutics·Michinao HashimotoDaniel S Kohane
Apr 2, 2020·ACS Central Science·Bruno G De Geest
Jan 23, 2018·Journal of the American Chemical Society·Kacper SkakujChad A Mirkin
Sep 22, 2021·International Journal of Pharmaceutics·Ashutosh SharmaHelen Hughes

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