Renewable Time-Responsive DNA Circuits

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Sudhanshu GargJohn Reif

Abstract

DNA devices have been shown to be capable of evaluating Boolean logic. Several robust designs for DNA circuits have been demonstrated. Some prior DNA-based circuits are use-once circuits since the gate motifs of the DNA circuits get permanently destroyed as a side effect of the computation, and hence cannot respond correctly to subsequent changes in inputs. Other DNA-based circuits use a large reservoir of buffered gates to replace the working gates of the circuit and can be used to drive a finite number of computation cycles. In many applications of DNA circuits, the inputs are inherently asynchronous, and this necessitates that the DNA circuits be asynchronous: the output must always be correct regardless of differences in the arrival time of inputs. This paper demonstrates: 1) renewable DNA circuits, which can be manually reverted to their original state by addition of DNA strands, and 2) time-responsive DNA circuits, where if the inputs change over time, the DNA circuit can recompute the output correctly based on the new inputs, that are manually added after the system has been reset. The properties of renewable, asynchronous, and time-responsiveness appear to be central to molecular-scale systems; for example, self-regulat...Continue Reading

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Citations

Sep 11, 2019·Chemical Communications : Chem Comm·Xiang LiHaojun Liang
Jan 9, 2020·Nature Communications·Fei WangChunhai Fan
Sep 12, 2020·Computational and Structural Biotechnology Journal·Xiaokang ZhangShihua Zhou
Apr 15, 2021·ACS Applied Materials & Interfaces·Kimberly L BerkMatthew W Lux
Jun 18, 2019·Bio Systems·Samuel J EllisJames I Lathrop
Jun 9, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sahana Gangadharan, Karthik Raman
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hui LvFei Wang
Jul 8, 2021·ACS Nano·Wonjin LeeYoungjun Song
Sep 21, 2019·Journal of the American Chemical Society·Cheng ZhangHao Yan
Mar 22, 2019·Nano Letters·Shalin ShahJohn Reif
May 24, 2019·ACS Nano·Xin Song, John Reif
Apr 6, 2019·ACS Synthetic Biology·Shalin ShahJohn Reif

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