Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution

The American Journal of Pathology
Ziad TouatJean-Baptiste Michel

Abstract

Human abdominal aortic aneurysm (AAA) expansion has been linked to the presence of a mural thrombus. Here we explored the mechanism of the continual luminal renewal of this thrombus and its ability to release biological markers potentially detectable in plasma. We also explored the ability of platelet inhibition to pacify the thrombus and to limit aneurysm progression in an experimental model. Blood samples and mural thrombi were collected in 20 AAA patients. In parallel, segments of sodium dodecyl sulfate-decellularized guinea pig aorta were xenografted onto the abdominal aorta of 30 rats to induce aneurysms. Fifteen rats received abciximab treatment and fifteen received irrelevant immunoglobulins. Procoagulant activity and platelet activation markers (microparticles, sP-selectin, sGPV, sCD40L) were increased threefold to fivefold in eluates from the luminal thrombus layer compared to other layers. All these markers were increased twofold to fivefold in patients' plasma compared to matched controls (P < 0.005). In the rat model, abciximab reduced both thrombus area and aneurysmal enlargement (P < 0.05). Platelet aggregation is probably responsible for the renewal of the thrombus in AAA. The luminal thrombus released markers of...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D WrightJ D Loike
Nov 18, 1996·Annals of the New York Academy of Sciences·A Ghorpade, B T Baxter
May 1, 1997·Journal of Vascular Surgery·R AdolphS C Watkins
Jan 7, 2000·The American Journal of Pathology·U SchönbeckP Libby
Sep 14, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtL Heickendorff
Sep 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Dougald M MonroeHarold R Roberts
Nov 5, 2002·The American Journal of Pathology·Vincent FontaineJean-Baptiste Michel
Nov 8, 2002·Journal of Vascular Surgery·Eric AllaireJean-Pierre Becquemin
Mar 5, 2003·Circulation·Yskert von KodolitschChristoph A Nienaber
Jun 20, 2003·Progress in Lipid Research·Barry R Lentz
May 27, 2004·The American Journal of Pathology·Vincent FontaineJean-Baptiste Michel
Jun 19, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·János KappelmayerHendra Setiadi
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Feb 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ian del CondeNeal S Kleiman
Apr 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Denisa D Wagner
May 4, 2005·Lancet·N SakalihasanO D Defawe
Jul 7, 2005·Circulation·Kevin K HannawaGilbert R Upchurch
Jul 13, 2005·Circulation·Jonathan L EliasonGilbert R Upchurch

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Citations

Apr 17, 2008·European Radiology·Jonathan GolledgePetra Buttner
Nov 28, 2009·Journal of Thrombosis and Thrombolysis·Paweł MatusikAnetta Undas
Feb 19, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·François RouzetDominique Le Guludec
Feb 10, 2009·Cardiovascular Research·Xavier HouardJean-Baptiste Michel
Nov 3, 2010·Cardiovascular Research·Jean-Baptiste MichelUNKNOWN FAD EU consortium
Jun 10, 2010·European Heart Journal·Jonathan GolledgePaul E Norman
Mar 1, 2013·Journal of Biomechanical Engineering·Giampaolo Martufi, T Christian Gasser
Mar 1, 2013·Journal of Biomechanical Engineering·J S WilsonJ D Humphrey
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
May 18, 2012·Circulation. Cardiovascular Imaging·Denis B Buxton
Jun 16, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Luciano de Figueiredo BorgesJean-Baptiste Michel
Jan 16, 2015·European Heart Journal Cardiovascular Imaging·Natzi SakalihasanJean-Baptiste Michel
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
Oct 8, 2013·Journal of Vascular Surgery·Jonathan GolledgePhilip J Walker
Sep 2, 2014·Journal of Vascular Surgery·Sandrine DelboscJean-Baptiste Michel
Jul 31, 2013·Neurologic Clinics·Philipp TausskyRicardo A Hanel
Oct 12, 2010·Current Problems in Cardiology·Joseph V MoxonJonathan Golledge
Mar 10, 2009·Thrombosis Research·Jonas WallinderAnders E Henriksson
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Balakrishnan SivaramanAnand Ramamurthi
Aug 19, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Femke A M V I HellenthalGeert Willem H Schurink
Jun 13, 2008·Journal of Biomechanics·N AssoulI Bataille
Jul 11, 2009·The British Journal of Surgery·D J ParryD J A Scott
Jun 4, 2014·Proteomics. Clinical Applications·Roxana Martinez-PinnaJose Luis Martin-Ventura
Nov 23, 2006·Blood Reviews·Andrea PiccinOwen P Smith
Jun 28, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C Behr-RasmussenJ S Lindholt
Jul 14, 2010·Journal of Vascular Surgery·Duncan J ParryD Julian A Scott
Jun 3, 2011·Atherosclerosis·Maggie FolkessonJesper Swedenborg
Aug 3, 2013·European Journal of Radiology·Louise de la MotteLars Lonn
Nov 13, 2012·Journal of Vascular Surgery·Jean-Marc AlsacJean-Baptiste Michel
Dec 2, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S ShantikumarD J A Scott
Jan 25, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J-M AlsacJ-B Michel
May 21, 2011·Atherosclerosis·Jonathan Golledge, Paul E Norman
Aug 26, 2014·Cytokine·Sofia Nessvi OtterhagBengt Lindblad

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