Renin-aldosterone responsiveness in uncomplicated juvenile-type diabetes mellitus

Hormone Research
S MossC A Vaamonde

Abstract

The changes in plasma renin activity (PRA) and plasma aldosterone concentration (PA) in response to dietary sodium restriction and upright posture were evaluated in 7 patients with juvenile-type, insulin-dependent, uncomplicated diabetes mellitus and in 5 healthy volunteers. All patients had normal blood pressure, 24-hour urine protein excretion and endogenous creatinine clearance. Renal sodium conservation and concentrating ability were grossly normal and 5 patients so tested, had normal renal acidification. PRA and PA were normal in every subject suggesting that abnormalities of the renin-aldosterone axis are late complications of diabetes mellitus usually associated with hypertension and nephropathy or neuropathy.

Citations

Dec 1, 1985·Irish Journal of Medical Science·J A O'HareD J O'Sullivan
Jan 1, 1979·Irish Journal of Medical Science·J B FerrissD J O'Sullivan
Apr 8, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·P McNairI Transbøl
Nov 1, 1981·Clinics in Endocrinology and Metabolism·J R Sowers, M L Tuck
Sep 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·C C CroninJ B Ferriss
Sep 1, 1982·Clinical Endocrinology·J B FerrissD J O'Sullivan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.