PMID: 107594Apr 1, 1979

Renin aldosterone system and potassium levels in chronic lead intoxication

Southern Medical Journal
J J GonzalezC B Loadholt

Abstract

Renin activity and aldosterone were evaluated relative to potassium levels and lead intoxication in 33 patients with a history of "moonshine" ingestion. Patients were divided into three groups: I, lead intoxicated with hyperkalemia; II, lead intoxicated without hyperkalemia; and III, not lead intoxicated without hyperkalemia. Those in group I demonstrated suppressed plasma renin activity, baseline and after furosemide, and blunted aldosterone responsiveness to furosemide. Plasma renin activity was not different in groups II and III, whereas aldosterone responsiveness was less in group II than in III. Group I patients tended to be older, had lower creatinine clearances, and six of nine had mild hyperchloremic acidosis. Diabetes and cortisol insufficiency were not present. Chronic lead intoxication due to illicit alcohol ingestion is associated with hyporeninemic hypoaldosteronism and hyperkalemia which appear to develop as the lead nephropathy progresses with duration and/or aging.

Citations

Jun 1, 1988·Environmental Health Perspectives·A J Vander
Apr 1, 1993·The American Journal of the Medical Sciences·V Batuman
Aug 5, 1998·Kidney International·A Rastegar, M Kashgarian
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·P LeeL V Campbell
Feb 14, 2003·Environmental Research·Rachel B KaufmannThomas D Matte
Jul 31, 2013·Biochemical and Biophysical Research Communications·Hwee-Yeong NgChien-Te Lee
Mar 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·M D Willard
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Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Krebiozen
Edetic Acid, Sodium Salt
Salix - substance
Hyperkalemia
Lead Poisoning
Potassium
Preprorenin

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