Sep 15, 1998

Renin-aldosterone system can respond to furosemide in patients with hyperkalemic hyporeninism

The Journal of Laboratory and Clinical Medicine
R ChanP M Zabetakis


Thirty-four patients (65.3+/-3.3 years of age, mean+/-SEM) with hyperkalemia (serum potassium >5.0 mEq/L) had measurement of their renin-aldosterone system. Nineteen patients (56%) had plasma renin activity (PRA) >1.5 ng/mL/h, which was not low, while 15 (44%) had PRA <1.5. Twelve of the 15 hyporeninemic hyperkalemic patients were studied to determine whether their renin-aldosterone system responded to 2 weeks of furosemide, 20 mg daily. Four were nonresponders: PRA averaged 0.3+/-0.1 ng/mL/h, and it did not increase with furosemide or respond to captopril before or after furosemide. Eight patients were responders: PRA averaged 0.6+/-0.2 ng/mL/h and increased with furosemide to 5.5+/-3.4 ng/mL/h. Captopril failed to increase PRA before furosemide, but PRA increased to 15.3+/-8.4 ng/mL/h after furosemide. Plasma aldosterone was low in both nonresponders and responders (3.5+/-1.2 ng/dL vs 5.8+/-2.5 ng/dL) and did not increase significantly with furosemide (4.3+/-1.7 ng/dL vs 8.7+/-2.5 ng/dL). Serum potassium did not fall and therefore did not limit the rise in aldosterone. Renin responders had greater body weight, were predominantly female (6/8 vs 2/4) and were more likely to have diabetes mellitus (7/8 vs 0/4). Plasma atrial nat...Continue Reading

  • References23
  • Citations3


  • References23
  • Citations3


Mentioned in this Paper

Aldosterone Measurement
Atrial Natriuretic Factor Precursors
Weighing Patient
Salix - substance
Serum Potassium Measurement
Hyperkalemic Periodic Paralysis
Atrial Natriuretic Factor (ANF) Measurement
Gene Expression

About this Paper

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Leslie TougerKhalid S Hasan
Clinical Journal of the American Society of Nephrology : CJASN
Trang Q NguyenOrson W Moe
Cardiovascular Drugs and Therapy
G GiebischR Unwin
© 2020 Meta ULC. All rights reserved