Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma

British Journal of Cancer
Lucienne Juillerat-JeanneretJ-M Gasc

Abstract

The expression and function in growth and apoptosis of the renin-angiotensin system (RAS) was evaluated in human glioblastoma. Renin and angiotensinogen (AGT) mRNAs and proteins were found by in situ hybridisation and immunohistochemistry in glioblastoma cells. Angiotensinogen was present in glioblastoma cystic fluids. Thus, human glioblastoma cells produce renin and AGT and secrete AGT. Human glioblastoma and glioblastoma cells expressed renin, AGT, renin receptor, AT(2) and/or AT(1) mRNAs and proteins determined by RT-PCR and/or Western blotting, respectively. The function of the RAS in glioblastoma was studied using human glioblastoma cells in culture. Angiotensinogen, des(Ang I)AGT, tetradecapaptide renin substrate (AGT1-14), Ang I, Ang II or Ang III, added to glioblastoma cells in culture, did not modulate their proliferation, survival or death. Angiotensin-converting enzyme inhibitors did not diminish glioblastoma cell proliferation. However, the addition of selective synthetic renin inhibitors to glioblastoma cells decreased DNA synthesis and viable tumour cell number, and induced apoptosis. This effect was not counterbalanced by concomitant addition of Ang II. In conclusion, the complete RAS is expressed by human gliobl...Continue Reading

References

Aug 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pilar BlancafortCarlos F Barbas
May 14, 2010·The Journal of Biological Chemistry·Artavazd TadevosyanStanley Nattel
Apr 3, 2009·Journal of Human Hypertension·T Rosenthal, I Gavras
Mar 1, 2006·Expert Opinion on Biological Therapy·K InoF Kikkawa
Nov 23, 2010·Clinical Science·Genevieve Nguyen
Oct 13, 2016·Frontiers in Surgery·Amy Ruth BradshawTinte Itinteang
Oct 18, 2005·Regulatory Peptides·Richard N Re, Julia L Cook
Feb 27, 2018·Current Hypertension Reports·Sharon D B de MoraisIrving H Zucker
Feb 10, 2018·Journal of Neuro-oncology·Caroline HappoldEORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups
Jun 7, 2006·British Journal of Cancer·M TahmasebiG P Vinson
Dec 13, 2006·Circulation Research·Walmor C De Mello
Dec 17, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Heiko Funke-KaiserThomas Unger
Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Nicolas ClereDaniel Henrion
Oct 23, 2010·Nature Reviews. Cancer·Amee J GeorgeRoss D Hannan
Jul 27, 2004·Oncogene·Atsushi SuzukiHiroyasu Esumi
Dec 2, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Dolores ArjonaJuan A Rey
Dec 22, 2011·British Journal of Cancer·Nobuyuki TanakaMototsugu Oya
Jan 29, 2008·Journal of Clinical Pharmacology·Richard N Re, Julia L Cook
Oct 30, 2018·CNS & Neurological Disorders Drug Targets·María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
Feb 19, 2015·Annals of Surgical Oncology·Akira MiyajimaMototsugu Oya
Aug 9, 2012·Annals of Surgical Oncology·Kazuyuki YugeMototsugu Oya
May 24, 2019·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mehdi GhasemiIbrahim C Haznedaroglu
Nov 2, 2018·PloS One·Alexander Perdomo-PantojaTalia Wegman-Ostrosky
Aug 19, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Qiong WangGang Wu
Apr 7, 2006·Médecine sciences : M/S·Sylvie CazaubonClara Nahmias
Apr 6, 2019·Frontiers in Surgery·Rosanna M A RahmanTinte Itinteang
Jun 15, 2020·Cellular and Molecular Neurobiology·José Alberto Carlos-EscalanteTalia Wegman-Ostrosky
Oct 8, 2011·Journal of Neuro-oncology·Maud ClemessyLucienne Juillerat-Jeanneret

Citations

Jul 1, 1991·Hypertension·W FischliQ Branca
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A MilstedCarlos M Ferrario
Oct 1, 1988·American Journal of Clinical Pathology·A ArizaE E Manuelidis
Dec 1, 1986·Journal of Clinical Pathology·W A ReidJ Kay
Feb 1, 1985·Journal of Biochemistry·S TakahashiY Miyake
Jan 1, 1981·Acta Neuropathologica·A C DiserensS Carrel
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E T BaldwinJ W Erickson
Dec 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·M K ReddyA Molteni
Jan 1, 1997·British Journal of Cancer·E R InwangG P Vinson
Dec 22, 1998·Biochimica Et Biophysica Acta·J DeinumM A Schalekamp
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M TahmasebiG P Vinson
Jun 9, 1999·Bioorganic & Medicinal Chemistry Letters·E VieiraW Wostl
Jun 9, 1999·Bioorganic & Medicinal Chemistry Letters·R GüllerH P Märki
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·L P EberlLucienne Juillerat-Jeanneret
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lucienne Juillerat-JeanneretF Pinet
Nov 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·G EgidyLucienne Juillerat-Jeanneret
May 12, 2001·Il Farmaco·H P MärkiR Zell
Jul 4, 2001·Biochemical Pharmacology·J AchardL A Fernandez
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Koki HirasawaHiroyuki Hanai
Feb 16, 2002·Hypertension·Jerome CelerierPierre Corvol
May 2, 2002·Anti-cancer Drugs·Hitoshi YoshijiHiroshi Fukui

Related Concepts

Glioblastoma Multiforme
Immunohistochemistry
Apoptosis, Intrinsic Pathway
Serine Proteinase Inhibitors, Exogenous
Renin-Angiotensin Pathway
Western Blotting
AGXT gene
Chinese Hamster Ovary Cell
Tumor Lysis Syndrome
Reverse Transcriptase Polymerase Chain Reaction

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Gunter Wolf
Pflügers Archiv : European journal of physiology
John W Wright, Joseph W Harding
© 2020 Meta ULC. All rights reserved