Jan 1, 1976

Renin and hemodynamic changes via central adrenergic, cholinergic, and sodium receptor mechanisms in conscious rats

Proceedings of the Society for Experimental Biology and Medicine
M MorrisWilliam A Pettinger

Abstract

The effects of centrally administered autonomic drugs and hypertonic saline on renin release were studied in the conscious rat. A 0.3 mug intraventricular dose of isoproterenol, which is one-thirtieth of the intraperitoneal dose required to stimulate renin release, induced the release of renin into the systemic circulation. Norepinephrine had no effect on renin release in the same dose range. Hypertonic saline and carbachol suppressed renin release. Alterations in renin release were preceded by a reciprocal change in blood pressure. These results suggest a central nervous system site for sodium, beta-adrenergic, and cholinergic receptors in altering renin release and blood pressure.

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Mentioned in this Paper

Carboptic
Ren
Diastolic Blood Pressure
Brain
Muscle Hypertonia
Adrenergic Agonists
Entire Central Nervous System
Autonomic Agents
Norepinephrine, (+, -)-Isomer
Cholinergic Receptors

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