PMID: 6991053Jun 9, 1980Paper

Renin and prorenin in hog brain: ubiquitous distribution and high concentration in the pituitary and pineal

Brain Research
S HiroseR J Workman

Abstract

With the objective of clarifying the nature of renin-like activity in the brain, we have devised methods to distinguish true renin from acid protease. These methods were used to determine the regional distribution of true renin in hog brain. The pineal was found to be the richest source of renin followed by the adenohypophysis and choroid plexus. The hypothalamus, cerebellum and amygdala contained moderately high concentrations of renin. Renin concentration in the neurohypophysis was negligible. Many regions contained activatable prorenin. The molecular weight and the pH-dependence of the brain renin were identical to these same properties of renal and plasma renins. Based upon its specific affinity to concanavalin A, brain renin was judged to be a glycoprotein. The electrofocusing pattern of renin from different regions of the brain differed from that of plasma and kidney renins, a discrepancy which could be interpreted as evidence for the endogenous synthesis of renin in the brain.

References

Feb 10, 1978·Biochimica Et Biophysica Acta·E HackenthalU Hilgenfeldt
Jan 1, 1978·Neuroendocrinology·M I Phillips
Dec 1, 1978·Clinical Science and Molecular Medicine. Supplement·T InagamiS Hirose
Jul 1, 1975·Journal of Neurochemistry·M M PothM Ward
Feb 18, 1977·Brain Research·N E SirettJ I Hubbard
Aug 1, 1977·Circulation Research·I A Reid
Dec 15, 1978·Brain Research·J A LewickiM P Printz
Jan 1, 1975·Neuropharmacology·C B DaulR E Garey
Jul 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D G ChangarisL C Keil
Mar 1, 1976·Clinical and Experimental Pharmacology & Physiology·D GantenH Fischer
May 31, 1976·The American Journal of Medicine·D GantenU Ganten
Feb 1, 1975·Endocrinology·I HaulicaL Ionescu
Dec 1, 1971·The American Journal of Physiology·D GantenJ Genest
Feb 1, 1971·The Journal of Experimental Medicine·C Fischer-FerraroS Finkielman
Oct 1, 1972·Journal of Neurochemistry·H Y Yang, N H Neff
Sep 21, 1973·Science·J B Simpson, A Routtenberg
Dec 15, 1971·Biochimica Et Biophysica Acta·H R Williams, T Y Lin

❮ Previous
Next ❯

Citations

Mar 1, 1984·Neurochemical Research·A Pope, R A Nixon
Feb 1, 1991·Cardiovascular Drugs and Therapy·D GantenR E Lang
Mar 8, 2005·Current Hypertension Reports·Koji Sakai, Curt D Sigmund
Oct 19, 1987·Life Sciences·R B MoffettA Husain
May 16, 1998·Brain Research. Molecular Brain Research·O BaltatuM Bader
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T OkamuraT Inagami
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K NaruseT Inagami
Jun 1, 1990·Journal of Neuroendocrinology·W G Thomas, C Sernia
Aug 1, 1991·Journal of Neurochemistry·I R SiemensJ W Harding
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T InagamiH Yokosawa
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·N BassoA C Taquini
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·K MurakamiH Miyazaki
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·H OhashiC Kawai
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·H WatariS Fukuchi
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·T A JenkinsF A Mendelsohn
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·R C SpethC M Ferrario
Feb 1, 1985·Journal of Neurochemistry·K MizunoS Fukuchi
Aug 1, 1985·Journal of Neurochemistry·K MizunoS Fukuchi
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Jan 1, 1988·Archives of Andrology·A OkuyamaT Sonoda
Jul 23, 1998·Physiological Reviews·J T Fitzsimons
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·J J MullinsK W Gross
Nov 15, 1984·Biochemical Pharmacology·D GantenT Unger
Dec 16, 1985·Life Sciences·K MizunoS Fukuchi
Aug 31, 1981·Brain Research·G SpeckD Ganten
Apr 15, 1988·Biochemical and Biophysical Research Communications·H ShionoiriS Hirose

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.