Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis

Heart Asia
Jacob Y CaoSean Lal

Abstract

The benefits of inhibiting the renin-angiotensin-aldosterone system (RAAS) are well established for left ventricular dysfunction, but remain unknown for right ventricular (RV) dysfunction. The aim of the current meta-analysis is to investigate the role of RAAS inhibition on RV function in those with or at risk of RV dysfunction. Medline, PubMed, EMBASE and Cochrane Libraries were systematically searched and 12 studies were included for statistical synthesis, comprising 265 RAAS inhibition treatment patients and 265 placebo control patients. The treatment arm showed a trend towards increased RV ejection fraction (weighted mean difference (WMD)=0.95, 95% CI -0.12 to 2.02, p=0.08) compared with the control arm. Subgroup analysis demonstrated a trend towards improvement in RV ejection fraction in patients receiving angiotensin receptor blockers compared with control (WMD=1.11, 95% CI -0.02 to 2.26, p=0.06), but not in the respective comparison for ACE inhibitors (WMD=0.07, 95% CI -2.74 to 2.87, p>0.05). No differences were shown between the two groups with regard to maximal oxygen consumption, RV end-systolic volume, RV end-diastolic volume, duration of cardiopulmonary exercise testing, and resting and maximal heart rate. Mild adve...Continue Reading

References

Feb 15, 1996·The American Journal of Cardiology·W E Hopkins, D P Kelly
Jan 1, 1997·Journal of the American College of Cardiology·M GelattR M Freedom
Apr 18, 2000·Lancet·T Thum, J Borlak
Mar 7, 2001·The American Journal of Cardiology·S J HechterG Webb
May 3, 2002·Journal of the American College of Cardiology·Leonardo A M ZornoffUNKNOWN SAVE Investigators
Nov 11, 2008·Journal of Cardiac Failure·Beth D KaufmanSeema Mital
Feb 13, 2010·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Serife Savaş BozbaşFüsun Oner Eyüboğlu
Sep 17, 2010·International Journal of Cardiology·Oktay TutarelMechthild Westhoff-Bleck
Jan 21, 2016·Circulation·Karen K StoutUNKNOWN American Heart Association Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Cou
Mar 31, 2016·IJC Heart & Vasculature·Stine AndersenJens Erik Nielsen-Kudsk

❮ Previous
Next ❯

Citations

Sep 12, 2019·F1000Research·Jelle P G van der VenWillem A Helbing
Aug 28, 2021·International Journal of Environmental Research and Public Health·Argen MamazhakypovOleg Pak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.