PMID: 8463901Apr 1, 1993Paper

Renin-angiotensin-aldosterone system in healthy subjects aged ten to eighteen years

The Journal of Pediatrics
Gregory A HarshfieldD A Pulliam

Abstract

We obtained normative data for plasma renin activity (PRA) and plasma aldosterone concentration from a biracial sample of 195 healthy, normotensive children and adolescents aged 10 to 18 years. The sample included 119 boys and 76 girls, of whom 103 were black and 92 were white. The mean PRA value (+/- SD) was 2.52 +/- 1.95 ng/ml per hour, with minimal and maximal values of 0.1 and 13.50 ng/ml per hour. The mean plasma aldosterone concentration was 12.56 +/- 8.59 ng/ml, with minimal and maximal values of 1.6 and 50.1 ng/ml. We also examined the effects of subject characteristics and electrolyte intake. The slope relating sodium excretion to PRA was negative and highly significant (slope = -0.01; p < 0.003). The slope relating PRA to plasma aldosterone concentration was positive and highly significant (slope = 1.59; p < 0.0001). We did not observe differences in either variable as a function of age, sex, race, or family history of hypertension. These results suggest that differences based on race and family history of hypertension observed in adults are not present in youth.

References

Aug 1, 1979·Kidney International·K J Van AckerH M Neels
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J SassardJ F Cier
Nov 8, 1975·British Medical Journal·M J Dillon, J M Ryness
Feb 1, 1992·Hypertension·A K ManatungaJ H Pratt
Jan 1, 1988·Journal of Cardiovascular Pharmacology·P Weidmann, C Beretta-Piccoli
Jan 1, 1988·Journal of Cardiovascular Pharmacology·R G DluhyR R Williams
Oct 26, 1989·The New England Journal of Medicine·J H PrattN S Fineberg
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·T A KotchenJ M Kotchen

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Citations

Jul 19, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Abdel Hakeem Abdel MohsenMohamed Abdel Maksood
Mar 1, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Simonetta CostaFrancesca Gallini

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