PMID: 15362513Sep 15, 2004Paper

Renin-angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetes

Molecular and Cellular Biochemistry
Jarmila MachackovaN S Dhalla

Abstract

Previous studies have shown that the renin-angiotensin system (RAS) is activated in diabetes and this may contribute to the subcellular remodelling and heart dysfunction in this disease. Therefore, we examined the effects of RAS blockade by enalapril, an angiotensin-converting enzyme inhibitor, and losartan, an angiotensin receptor AT1 antagonist, on cardiac function, myofibrillar and myosin ATPase activity as well as myosin heavy chain (MHC) isozyme expression in diabetic hearts. Diabetes was induced in rats by a single injection of streptozotocin (65 mg/kg; i.v.) and these animals were treated with and without enalapril (10 mg/kg/day; oral) or losartan (20 mg/kg/day; oral) for 8 weeks. Enalapril or losartan prevented the depressions in left ventricular rate of pressure development, rate of pressure decay and ventricular weight seen in diabetic animals. Both drugs also attenuated the decrease in myofibrillar Ca2+-ATPase, Mg2+-ATPase and myosin ATPase activity seen in diabetic rats. The diabetes-induced increase in beta-MHC content and gene expression as well as the decrease in alpha-MHC content and mRNA levels were also prevented by enalapril and losartan. These results suggest the occurrence of myofibrillar remodelling in dia...Continue Reading

Citations

Jul 16, 2008·Current Diabetes Reports·Romain Harmancey, Heinrich Taegtmeyer
Aug 23, 2006·Molecular and Cellular Biochemistry·Walmor C De Mello
Aug 19, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tom BäcklundMika Laine
Dec 2, 2017·Heart Failure Reviews·Raphael M SinghJaipaul Singh
Feb 8, 2006·Canadian Journal of Physiology and Pharmacology·Jarmila MachackovaNaranjan S Dhalla
Aug 27, 2009·Acta Physiologica Hungarica·Kenichi WatanabeY Aizawa
Dec 25, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Ramesh K GoyalNaranjan S Dhalla
Feb 26, 2013·Heart Failure Reviews·Naranjan S DhallaVijayan Elimban
Mar 5, 2013·Heart Failure Reviews·Adriana Adameova, Naranjan S Dhalla
Apr 5, 2020·International Journal of Molecular Sciences·Naranjan S DhallaParamjit S Tappia
Dec 8, 2006·Annals of the New York Academy of Sciences·Xueliang LiuNaranjan S Dhalla
Dec 23, 2011·Biological Trace Element Research·Yang LiuDe-bin Wang
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