Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation

Pulmonary Pharmacology & Therapeutics
Di WangShan-Shan Hu

Abstract

While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

Citations

Apr 26, 2020·British Journal of Pharmacology·Krishna Sriram, Paul A Insel
Jun 7, 2020·Cancers·Maria Joana CatarataRui Medeiros
Apr 9, 2020·Annals of the American Thoracic Society·Meagan E Deming, Wilbur H Chen
Apr 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Miguel Álvarez-AragónInmaculada Álvarez-López
Jun 10, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A A F de Vries
Jul 9, 2020·Frontiers in Physiology·Giselle Santos MagalhaesRobson A Souza Santos
Oct 1, 2020·BMC Endocrine Disorders·Flavio A Cadegiani
Sep 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Maureen CzickRobert Shapter
Oct 13, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Galit H FrydmanGregory Piazza
Nov 1, 2020·International Journal of Molecular Sciences·Jaroslav Hrenak, Fedor Simko
Nov 26, 2020·International Journal of Molecular Sciences·Alice G VassiliouStylianos E Orfanos
Jan 1, 2021·Alzheimer's Research & Therapy·Scott MinersSeth Love
Oct 27, 2020·Frontiers in Cardiovascular Medicine·Limin SongXiangdong Chen
Jan 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Murat Oz, Dietrich Ernst Lorke
Mar 11, 2021·Journal of Pharmaceutical Investigation·Doaa A GhareebMaha A El-Demellawy
May 30, 2020·Biochemical Pharmacology·Manar Mohammed El Tabaa, Maram Mohammed El Tabaa
Aug 28, 2021·Biomedicines·Francesco NappiSanjeet Singh Avtaar Singh

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
AECs
bronchoalveolar lavage
lavage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Anaesthesia
R Fletcher
Minerva anestesiologica
J L Vincent
Journal of General Internal Medicine
P J Cozzi
American Journal of Respiratory and Critical Care Medicine
Hemang YadavOgnjen Gajic
© 2021 Meta ULC. All rights reserved