Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I

Hypertension
L M de LannoyM A Schalekamp

Abstract

We used a modification of the isolated perfused rat heart, in which coronary effluent and interstitial transudate were separately collected, to investigate the uptake and clearance of exogenous renin, angiotensinogen, and angiotensin I (Ang I) as well as the cardiac production of Ang I. The levels of these compounds in interstitial transudate were considered to be representative of the levels in the cardiac interstitial fluid. During perfusion with renin or angiotensinogen, the steady-state levels (mean +/- SD) in interstitial transudate were 64 +/- 34% (P < .05 for difference from the arterial level, n = 8) and 108 +/- 42% (n = 6) of the arterial level, respectively; the levels in coronary effluent were not significantly different from those in interstitial transudate. Ang I was not detectable in interstitial transudate during perfusion with Tyrode's buffer or angiotensinogen. It was very low in interstitial transudate during perfusion with renin and rose to much higher levels during combined renin and angiotensinogen perfusion. The total production rate of Ang I present in interstitial fluid could be largely explained by the renin-angiotensinogen reaction in the fluid phase of the interstitial compartment. In contrast, the to...Continue Reading

References

Feb 1, 1975·The Australian Journal of Experimental Biology and Medical Science·S L SkinnerN H Fidge
Jul 29, 1977·Pflügers Archiv : European journal of physiology·E A De Deckere, P Ten Hoor
Jan 1, 1992·Journal of Hypertension·T OkamuraN Toda
Aug 1, 1992·The American Journal of Physiology·L A McNabney, D A Essig
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Mar 1, 1990·Endocrinology·J DeinumM A Schalekamp
Feb 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·J GutkowskaJ Genest
Apr 13, 1984·European Journal of Pharmacology·W H Van GilstC D De Langen
Jan 29, 1980·Biochemical and Biophysical Research Communications·H JansenW C Hülsmann
Jul 1, 1994·Hypertension·A H DanserM A Schalekamp
Oct 1, 1993·Hypertension·D J CampbellA M Duncan
Jul 1, 1993·Trends in Cardiovascular Medicine·J E Schnitzer

❮ Previous
Next ❯

Citations

Nov 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Wenxia Chai, A H Jan Danser
Mar 8, 2005·Current Hypertension Reports·Wenxia Chai, A H Jan Danser
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·A H Jan Danser
Nov 7, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·A H Jan Danser
Jan 12, 2002·British Journal of Pharmacology·Martin P SchuijtA H Jan Danser
Feb 4, 2010·Journal de la Société de biologie·Diane BracquartGeneviève Nguyen
Aug 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xifeng LuAlexander H Jan Danser
Jul 14, 1999·Journal of Hypertension·P J AdmiraalM A Schalekamp
Mar 7, 2000·Journal of Hypertension·M P SchuijtA H Danser
May 1, 2001·Journal of Hypertension·J P van KatsA H Danser
Oct 3, 2002·Journal of Hypertension·Mark M E D van den EijndenA H Jan Danser
Jul 14, 2010·Journal of Hypertension·Joep H M van EschA H Jan Danser
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·A H Jan Danser
Feb 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Carlos M FerrarioJames R Sowers
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daniel F Catanzaro
Jan 9, 2013·Current Hypertension Reports·Lodi C W RoksnoerA H Jan Danser
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·Jasmina Varagic, Edward D Frohlich
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·A H Jan Danser, Jasper J Saris
Jun 8, 2013·Journal of Hypertension·Frederik PerssonHans-Henrik Parving
May 5, 2004·Médecine sciences : M/S·Jean-Baptiste Michel
Feb 22, 2012·Expert Opinion on Investigational Drugs·Koen VerdonkJoep H M van Esch
May 5, 2006·Kidney International·G Nguyen
May 14, 2010·European Journal of Pharmacology·Manne KropA H Jan Danser
Apr 19, 2005·British Journal of Pharmacology·Wenxia ChaiA H Jan Danser
Nov 22, 2008·European Journal of Clinical Investigation·J J KuiperA H van den Meiracker
Apr 22, 2015·American Journal of Hypertension·A H Jan Danser
Apr 13, 2012·Clinical Science·Wendy W Batenburg, A H Jan Danser
Apr 21, 2011·Pharmacology & Therapeutics·Els MoltzerA H Jan Danser
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jin YangChing-Pin Chang
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Koki HirasawaHiroyuki Hanai
Apr 19, 2018·American Journal of Physiology. Renal Physiology·Anne D M Riquier-BrisonJános Peti-Peterdi
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.