Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement

Clinical Rheumatology
Ozan OzkayaEnver Hasanoğlu

Abstract

The clinical course of Henoch-Schönlein Purpura (HSP) in children is variable, with some patients having a much more rapidly progressing course than others. We investigated whether polymorphisms of the renin-angiotensin system (RAS) genes are involved in HSP. Three RAS genotypes were examined in 114 children with HSP and in 164 healthy children: the angiotensin I converting enzyme (ACE) insertion/deletion polymorphism, the M235T mutation in the angiotensinogen gene (Agt), and the A1166C in the angiotensin II type I receptor (AT1R) gene. Significant differences were observed between HSP patients and control group in the frequency of ACE and Agt genotypes (p=0.004 and p=0.003, respectively). The TT genotype of Agt gene was associated with a 3.5-fold increased risk for Henoch-Schönlein nephritis (HSN) compared with the MM/MT genotype (odds ratio, 3.5; 95% confidence interval, 1.2-10.4). There was a trend to a higher prevalence of the TT genotype of the Agt gene among patients with nephrotic range proteinuria when compared to the patients with mild proteinuria, although the difference did not reach a statistical significance. The results of this study suggest that polymorphisms of ACE gene and Agt gene likely influence the risk of ...Continue Reading

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Citations

Jan 18, 2013·Rheumatology International·Xuelian HeWei Yin
Jan 20, 2007·Clinical Rheumatology·Ozan OzkayaHaydar Ali Taşdemir
Jan 7, 2010·Current Opinion in Rheumatology·Paul A Monach, Peter A Merkel
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
May 21, 2013·Autoimmunity Reviews·Donato RiganteSusanna Esposito
Dec 17, 2009·European Journal of Pediatrics·Hugh J McCarthy, E Jane Tizard
Oct 29, 2014·Renal Failure·Song Mao, Songming Huang
Aug 13, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS· Desong Liu Zheng Wang
Mar 12, 2019·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Xiaoqing ZhangHuahong Zhang
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Young Ho LeeGwan Gyu Song
Feb 17, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marija Jelusic, Mario Sestan

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