Renin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement

Journal of the American College of Cardiology
Tania Rodriguez-GabellaIgnacio J Amat-Santos

Abstract

Several studies have demonstrated the benefits of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis, but the presence of persistent fibrosis and myocardial hypertrophy has been related to worse prognosis. The aim of this study was to explore the potential benefits of renin-angiotensin system (RAS) inhibitors on left ventricular remodeling and major clinical outcomes following successful transcatheter aortic valve replacement (TAVR). Patients from 10 institutions with severe aortic stenosis who underwent TAVR between August 2007 and August 2017 were included. All baseline data were prospectively recorded, and pre-specified follow-up was performed. Doses and types of RAS inhibitors at discharge were recorded, and matched comparison according to their prescription at discharge was performed. A total of 2,785 patients were included. Patients treated with RAS inhibitors (n = 1,622) presented similar surgical risk scores but a higher rate of all cardiovascular risk factors, coronary disease, and myocardial infarction. After adjustment for these baseline differences, reduction of left ventricular volumes and hypertrophy was greater and cardiovascular mortality at 3-year follow-up was lower (odds ratio: 0.5...Continue Reading

Citations

Jan 7, 2020·European Heart Journal·Ronald K BinderBernard Prendergast
Mar 25, 2020·Journal of Hypertension·Sahrai SaeedGiuseppe Mancia
Jul 1, 2020·Circulation. Cardiovascular Interventions·Vincent AuffretHervé Le Breton
Nov 16, 2019·Aging·Ignacio J Amat-SantosJavier López Diaz
Sep 8, 2020·Journal of the American Heart Association·Sachin S GoelSamir R Kapadia
Apr 21, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yinghao SunJianfang Luo
Feb 19, 2020·Expert Review of Cardiovascular Therapy·Sahrai SaeedJohn Chambers
Dec 11, 2019·European Heart Journal·Karola S Jering, Marc A Pfeffer
Nov 27, 2019·PloS One·Ulrich Fischer-RasokatWon-Keun Kim
Jan 11, 2020·Journal of the American College of Cardiology·Guanghua Tang, Xianshi Zhou
Jan 11, 2020·Journal of the American College of Cardiology·Tania Rodriguez-GabellaIgnacio J Amat-Santos
Nov 23, 2020·The American Journal of Cardiology·Danon KaewkesRaj Makkar
Aug 25, 2020·The Canadian Journal of Cardiology·Jakob LedwochChristian Kupatt
Nov 8, 2020·International Journal of Molecular Sciences·Maristella DonatoMarcello Rattazzi
May 14, 2020·Revista Española De Cardiología·Ignacio J Amat-SantosJosé A San Román
May 30, 2020·Journal of the American College of Cardiology·Ignacio J Amat-SantosJ Alberto San Román
Oct 26, 2021·European Journal of Heart Failure·Ignacio J Amat-SantosUNKNOWN Dapagliflozin after Transcatheter Aortic Valve Implantation (DapaTAVI) Investigators

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