Renin-angiotensin system inhibition improves coronary flow reserve in hypertension

Journal of Cardiovascular Pharmacology
E D Frohlich

Abstract

Angiotensin II not only elevates arterial pressure, it adversely alters hemodynamics and cardiovascular structure and exacerbates the course of hypertensive disease. Alterations in coronary hemodynamics, including reductions in coronary blood flow and flow reserve, reflect the pathophysiology of arteriolar disease and associated endothelial dysfunction thereby promoting coronary insufficiency and increasing overall cardiovascular risk. In spontaneously hypertensive rats, coronary flow reserve, the difference between basal coronary blood flow and the flow achieved during maximal coronary vasodilation achieved by physiological or pharmacological interventions, is drastically impaired at rest; however, it can be improved significantly by pharmacological agents that inhibit the renin-angiotensin system, alone or in combination. The combination of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin-II (type 1) receptor blocker, in equidepressor doses, markedly improved coronary flow reserve to levels seen in normotensive Wistar Kyoto rats after 12 weeks of treatment, while diminishing cardiovascular mass and improving systemic hemodynamics and ventricular metabolic demands. These findings suggest the potential merits...Continue Reading

References

Oct 22, 1979·The American Journal of Cardiology·E D Frohlich, R C Tarazi
Oct 1, 1992·The New England Journal of Medicine·E D FrohlichB Massie
Dec 1, 1989·Journal of Molecular and Cellular Cardiology·E D Frohlich
Feb 1, 1987·Circulation·E D Wigle
May 1, 1983·Journal of the American College of Cardiology·F G DunnE D Frohlich
Sep 1, 1983·Hypertension·E D FrohlichF G Dunn
Jul 15, 1997·The Journal of Clinical Investigation·H M Siragy, R M Carey
Aug 1, 1997·Journal of Molecular and Cellular Cardiology·C A van KesterenA H Danser
Nov 14, 1997·The Medical Clinics of North America·G F MitchellM A Pfeffer
Mar 25, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A BlumeT Unger
Aug 24, 1999·Hypertension·E D Frohlich
Feb 26, 2000·Cardiovascular Research·H Drexler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.