Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study

Cancer
Ronald van der KnaapB H Ch Stricker

Abstract

Angiotensin I-converting enzyme (ACE) inhibitors, angiotensin II antagonists, and the ACE insertion/deletion (I/D) gene polymorphism all influence serum angiotensin II action. Because angiotensin II levels have been associated with cancer, the objective of the current epidemiologic study was to investigate whether renin-angiotensin system inhibitors and/or ACE genotypes were associated with an altered risk of colorectal, lung, breast, and prostate cancer. Data were obtained from the Rotterdam Study, a population-based, prospective cohort study with 7983 participants. Participants who had a history of 1 of the cancers of interest (n = 216) or who had a medication history <6 months (n = 88) were excluded, leaving 7679 participants, of whom the ACE genotypes could be assessed in 6670 individuals. The mean follow-up was 9.6 years, during which 730 incident cancers occurred. The effect of medication, ACE I/D genotypes, and their interaction on cancer risk and progression was studied by using Cox proportional hazard models. Carriers of the high-activity genotype DD had an increased risk of breast cancer compared with low-activity II/ID genotype carriers (hazard ratio [HR], 1.47; 95% confidence interval [95% CI], 1.05-2.04), but no as...Continue Reading

References

Jul 1, 1991·European Journal of Epidemiology·A HofmanF A van den Ouweland
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 16, 1995·The New England Journal of Medicine·K LindpaintnerC H Hennekens
Jul 1, 1996·American Journal of Hypertension·M PahorR J Havlik
Feb 22, 1997·Lancet·H JickC R Meier
Sep 2, 1998·European Journal of Clinical Nutrition·K Klipstein-GrobuschJ C Witteman
Feb 11, 2000·Archives of Internal Medicine·C R MeierH Jick
Jul 24, 2001·European Heart Journal·E GrossmanU Goldbourt
Dec 16, 2003·The Prostate·Gunnar RonquistKurt Svärdsudd
May 28, 2004·Acta Oncologica·Henriette LindbergTorben Skovsgaard
Jul 29, 2004·Cancer Causes & Control : CCC·Linda PerronFrançois Meyer
Aug 19, 2004·Pharmacoepidemiology and Drug Safety·Antonio González-PérezLuis Alberto García Rodríguez
Aug 3, 2005·Trends in Endocrinology and Metabolism : TEM·Frédérique Deshayes, Clara Nahmias
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Angela M González-Zuloeta LaddCornelia van Duijn
Jun 23, 2006·Breast Cancer Research and Treatment·Jon P FryzekSøren Friis
Sep 7, 2006·Endocrine-related Cancer·J R PuddefootG P Vinson
Oct 18, 2006·The Prostate·Takeo KosakaMasamichi Hayakawa

❮ Previous
Next ❯

Citations

Apr 3, 2009·Journal of Human Hypertension·T Rosenthal, I Gavras
Oct 23, 2010·Nature Reviews. Cancer·Amee J GeorgeRoss D Hannan
Feb 22, 2012·Genetic Testing and Molecular Biomarkers·Sanja Dević PavlićAnđelka Radojčić Badovinac
Apr 24, 2012·Carcinogenesis·Ernest K AmankwahJong Y Park
Aug 5, 2011·Journal of the National Cancer Institute·Thomas P AhernTimothy L Lash
Jun 2, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A F CarpentierC Levy
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey PettyFrank M Torti
Aug 31, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Chan YoonSang Min Park
Jan 17, 2014·Journal of the National Cancer Institute·Mingyang Song, Edward L Giovannucci
Jul 1, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soha NamaziAhmad Hosseini
Jul 18, 2008·Carcinogenesis·Eleanor I AgerChristopher Christophi
Oct 29, 2015·European Journal of Clinical Investigation·Diana Moreno-MuñozEnrique Aranda
Aug 10, 2010·Regulatory Peptides·Gorka LarrinagaAdolfo Varona
Nov 26, 2009·Diabetes Research and Clinical Practice·Xilin YangJuliana C N Chan
Apr 23, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Sarah J SantosSandra Z Haslam
Oct 1, 2008·Molecular and Cellular Endocrinology·L ChowS N S Louis
Jul 26, 2011·The American Journal of Cardiology·Norela V OcampoRamdas G Pai
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Guldal Inal GultekinTurgay Isbir
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xin-Hong Pei, Hui-Xiang Li
May 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Soha NamaziNegar Azarpira
Apr 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuebing XieJing Chen
Feb 24, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julia KravchenkoIgor Akushevich
Oct 13, 2016·Frontiers in Surgery·Amy Ruth BradshawTinte Itinteang
Jan 15, 2017·European Journal of Pharmacology·Anna WzgardaBeata J Stanisz
May 7, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Meili SunYuping Sun
Dec 20, 2011·Endocrine-related Cancer·Gavin P VinsonJohn R Puddefoot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
A M González-Zuloeta LaddC M van Duijn
Journal of the Renin-angiotensin-aldosterone System : JRAAS
Silvana Aparecida Alves CorrêaIsmael Dale Cotrim Guerreiro da Silva
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Arzu YarenErgun Erdem
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Christoph RöckenMatthias P A Ebert
© 2021 Meta ULC. All rights reserved