Renin-angiotensin system may trigger kidney damage in NOD mice

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Juliana Almada ColucciDulce Elena Casarini

Abstract

Diabetic nephropathy is a complication of diabetes and one of the main causes of end-stage renal disease. A possible causal link between renin-angiotensin aldosterone system (RAAS) and diabetes is widely recognized but the mechanisms by which the RAAS may lead to this complication remains unclear. The aim of this study was to evaluate angiotensin-I converting enzyme (ACE) activity and expression in numerous tissues, especially kidney, of non-obese diabetic mouse. Kidney, lung, pancreas, heart, liver and adrenal tissues from diabetic and control female NOD mice were homogenized for measurement of ACE activity, SDS-PAGE and Western blotting for ACE and ACE2, immunohistochemistry for ACE and angiotensins I, II and 1-7 and bradykinin quantification. ACE activity was higher in kidney, lung and adrenal tissue of diabetic mice compared with control mice. In pancreas, activity was decreased in the diabetic group. Western blotting analysis indicated that both groups presented ACE isoforms with molecular weights of 142 and 69 kDa and a decrease in ACE2 protein expression. Angiotensin concentrations were not altered within groups, although bradykinin levels were higher in diabetic mice. The immunohistochemical study in kidney showed an in...Continue Reading

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Citations

Apr 30, 2013·Autonomic Neuroscience : Basic & Clinical·Oscar A MoraesMaria Cláudia Irigoyen
Mar 10, 2017·International Journal of Molecular Sciences·Heleia Roca-HoMaria Jose Soler
May 31, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heleia Roca-HoMarta Riera
Jul 23, 2020·British Journal of Pharmacology·Claudia PennaPasquale Pagliaro
Jul 7, 2020·Frontiers in Medicine·Pasquale Pagliaro, Claudia Penna
Feb 12, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Fernanda Barrinha FernandesDulce Elena Casarini
Jul 27, 2021·Saudi Journal of Biological Sciences·Ahmed ElshafeiMaher H Gomaa

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