Renin-angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis.

Modern Rheumatology
Nayara Felicidade Tomaz BrazAdriana Maria Kakehasi

Abstract

To compare serum levels of RAS components in women with RA versus healthy females and to investigate the association between these molecules and subclinical atherosclerosis. A cross-sectional study involving female RA patients without ischemic CVD. Disease activity was assessed using the DAS28 and the CDAI. IMT of the common carotid artery was evaluated by ultrasonography. Serum levels of Ang II, Ang-(1-7), ACE and ACE2 were determined by enzyme immunoassay. Fifty women with RA, mean 48.2 (7.3) years, were compared to 30 healthy women, paired by age. RA patients had higher plasma levels of Ang II (p < .01), Ang-(1-7) (p < .01), and ACE (p < .01) than controls. The ratios of ACE to ACE2 were higher in RA patients, whereas Ang II/Ang-(1-7) ratios were lower in RA patients. The presence of hypertension and the treatment with ACE inhibitors did not significantly modify serum levels of Ang II, Ang-(1-7), ACE and ACE2 in patients with RA. Seven RA patients had altered IMT, and eight patients exhibited atherosclerotic plaque. There was a negative correlation between ACE2 levels and IMT (p = .041). IMT positively correlated with age (p = .022), disease duration (p = .012) and overall Framingham risk score (p = .008). Ang II concentrati...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1994·British Journal of Pharmacology·D A WalshJ Wharton
Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Dec 7, 2002·Hypertension·Gabriele WiemerHolger Heitsch
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Aug 25, 2004·Hypertension·Sérgio Veloso Brant PinheiroRobson Augusto Souza Santos
Mar 8, 2005·Arthritis and Rheumatism·Hilal Maradit-KremersSherine E Gabriel
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Oct 14, 2005·Kidney International·Carlos M FerrarioMark C Chappell
Feb 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·James H SteinUNKNOWN American Society of Echocardiography Carotid Intima-Media Thickness Task Force
Oct 24, 2008·The American Journal of Medicine·Jane E Salmon, Mary J Roman
Feb 19, 2010·Current Opinion in Rheumatology·Elena Myasoedova, Sherine E Gabriel
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Jul 9, 2010·Fundamental & Clinical Pharmacology·Kimiaki KomukaiMichihiro Yoshimura
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cheng ZhangYihai Cao
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kátia Daniela da SilveiraMauro Martins Teixeira
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Mar 16, 2013·British Journal of Pharmacology·A C Simões e SilvaM M Teixeira
Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ana Cristina Simões E Silva, Mauro Martins Teixeira
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Jul 6, 2018·British Journal of Haematology·André R BelisárioAna C Simões E Silva
Dec 6, 2018·Bioscience Reports·Roberta da Silva FilhaAna Cristina Simões E Silva
Jul 3, 2019·Biology of Sex Differences·Melissa C WhiteAmy C Arnold

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