Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea

Cancer Investigation
M P CarreraJ M Martínez-Martos

Abstract

Pineal function has been considered particularly as a neuroendocrine modulator in hormone responsive tumors, like the hormone-dependent mammary tumors. The complexity of the gland function, moreover, is denoted by the presence of a local renin-angiotensin-system (RAS) that regulates melatonin biosynthesis. Classically, angiotensin II (Ang II) has been considered as the effector peptide of the RAS, but Ang II is not the only active peptide. Several of its degradation products, including angiotensin III (Ang III) and angiotensin IV (Ang IV) also possess biological functions. These peptides are formed via the activity of several aminopeptidases. Our aim is to know their role in the regulation of pineal RAS and breast cancer. Aminopeptidase N (APN), aminopeptidase B (APB) and aminopeptidase A (aspartyl- and glutamyl-aminopeptidase, APA) activities are measured in the pineal gland of rats with breast cancer induced by N-methyl nitrosourea (NMU). Aminopeptidase activities were measured fluorimetrically using their corresponding aminoacyl-beta-naphthylamides as substrates. Specific APN and APB activities in pineal gland of controls and NMU-treated rats were not modified. Aspartyl aminopeptidase activity significantly decreased in NMU-...Continue Reading

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Citations

Oct 10, 2014·International Journal of Molecular Sciences·Olga PechanovaFedor Simko
Aug 21, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Gorka LarrinagaJosé I López
Mar 20, 2012·Maturitas·María Jesús Ramírez-ExpósitoJosé Manuel Martínez-Martos
May 21, 2011·The Breast : Official Journal of the European Society of Mastology·José Manuel Martínez-MartosMaría Jesús Ramírez-Expósito
Apr 16, 2008·Journal of Neurochemistry·Nadia de MotaCatherine Llorens-Cortes
Dec 10, 2008·Nature Clinical Practice. Nephrology·Juan Carlos Q Velez
Jul 24, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria del Pilar CarreraJose Manuel Martínez-Martos
Jan 25, 2008·American Journal of Physiology. Renal Physiology·Lorena BlancoAdolfo Varona
Apr 3, 2019·Journal of Cardiovascular Development and Disease·Ali NehmeKazem Zibara
Nov 30, 2006·Indian Journal of Medical Sciences·T RavindraY R Ahuja

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