Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis.

International Journal of Radiation Oncology, Biology, Physics
Swarajit N GhoshMeetha Medhora

Abstract

To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10-15 Gy). Unanesthetized WAG/RijCmcr female rats received a single dose of X-irradiation (10, 12, or 15 Gy at 1.615 Gy/min) to the thorax. Captopril (an angiotensin-converting enzyme inhibitor) or losartan (an angiotensin receptor blocker) was administered in the drinking water after irradiation. Pulmonary structure and function were assessed after 8 weeks in randomly selected rats by evaluating the breathing rate, ex vivo vascular reactivity, and histopathologic findings. Survival analysis was undertaken on all animals, except those scheduled for death. Survival after a dose of 10 Gy to the thorax was not different from that of unirradiated rats for <or=1 year. Survival decreased to <50% by 45 weeks after 12 Gy and by 8-9 weeks after 15 Gy. Captopril (17-56 mg/kg/d) improved survival and reduced radiation-induced increases in breathing rate, changes in vascular reactivity, and histopathologic evidence of injury. Radiation-induced increases in the breathing rate were prevented even if captopril was started 1 week after irradiation or if it was discontinued after 5 weeks. Losartan, although effective in reducing mortality, was not as efficaci...Continue Reading

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Citations

Jul 31, 2012·Journal of Radiation Research·Meetha MedhoraAniko Szabo
Oct 26, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Meetha MedhoraJohn E Moulder
Aug 14, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robert C MolthenMeetha M Medhora
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