Abstract
Four groups of New Zealand rabbits were used to study the effect of suppressed plasma renin activity (PRA) on atherogenesis. Control groups were fed normal rabbit chow (Group I) or normal chow supplemented with 0.25% cholesterol--0.75% corn oil (Group III). Group II animals were fed normal chow and received periodic injections of 11-desoxycorticosterone (DOC)pivalate and 0.5% saline to drink, while Group IV animals were treated similarly except that they were also fed the atherogenic diet. Blood pressure and blood chemistry measurements were performed monthly over a 7-month period. The blood pressure was unaffected by either the diet or the DOC-saline treatment, however, the PRA was greatly reduced in the animals receiving DOC-saline (Groups II and IV). Similarly, plasma aldosterone was significantly (P less than 0.05) reduced in the DOC-saline-treated animals. No atheromata were observed in the animals consuming the regular diet, regardless of DOC-saline treatment. All of the animals fed the atherogenic diet showed extensive aortic atheromata. However, there was no difference in the lesion index between the animals with normal PRA levels (Group III) and those with suppressed PRA levels (Group IV). Likewise, microscopic evaluat...Continue Reading
References
Nov 1, 1975·Atherosclerosis·K N BrethertonS L Skinner
Jun 1, 1976·Circulation Research·R D BevanJ A Bevan
Feb 1, 1972·Endocrinology·J Menard, K J Catt
Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Oct 1, 1969·The Journal of Clinical Endocrinology and Metabolism·E HaberA Purnode
Sep 1, 1973·The American Journal of Medicine·J Giese
Apr 9, 1974·Biochemistry·V G ShoreR G Hart
Apr 1, 1974·Journal of Steroid Biochemistry·W NowaczynskiJ Genest
Jul 1, 1971·Thorax·C W BedrossianA G Foraker
Jan 1, 1981·Atherosclerosis·M L OverturfW M Kirkendall
Mar 1, 1953·The Journal of Clinical Endocrinology and Metabolism·G M C MASSONI H PAGE
Sep 1, 1953·The American Journal of the Medical Sciences·G M MASSONI H PAGE
Jul 1, 1954·The British Journal of Surgery·P M DANIELJ N WARD-McQUAID
Aug 1, 1958·Acta Endocrinologica·F GROSS, H SCHMIDT
Jan 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·A VERNIORY, P POTVLIEGE
Aug 1, 1964·Circulation·W HOLLANDERD M KRAMSCH
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·J GIESE
Jan 1, 1962·Journal of Atherosclerosis Research·D KRITCHEVSKYJ LANGAN
Citations
Jul 1, 1987·Atherosclerosis·M OverturfH Taegtmeyer
May 1, 1985·Circulation Research·A V ChobanianC Chan
Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGillC J Schwartz
Jun 1, 1983·Research in Nursing & Health·C N Hoskins
Sep 1, 1990·The Journal of Primary Prevention·W C WorkP A Wyman
Jun 17, 2004·Journal of Basic and Clinical Physiology and Pharmacology·Mustafa Edremitlioğlu, Gülsen Oner
Apr 1, 1982·Atherosclerosis·M L OverturfW M Kirkendall