PMID: 7037015Nov 1, 1981Paper

Renin as a risk factor for atherogenesis. Part 2. Effects of hypercholesterolemia and hyporeninemia in the rabbit

Atherosclerosis
M L OverturfW M Kirkendall

Abstract

Four groups of New Zealand rabbits were used to study the effect of suppressed plasma renin activity (PRA) on atherogenesis. Control groups were fed normal rabbit chow (Group I) or normal chow supplemented with 0.25% cholesterol--0.75% corn oil (Group III). Group II animals were fed normal chow and received periodic injections of 11-desoxycorticosterone (DOC)pivalate and 0.5% saline to drink, while Group IV animals were treated similarly except that they were also fed the atherogenic diet. Blood pressure and blood chemistry measurements were performed monthly over a 7-month period. The blood pressure was unaffected by either the diet or the DOC-saline treatment, however, the PRA was greatly reduced in the animals receiving DOC-saline (Groups II and IV). Similarly, plasma aldosterone was significantly (P less than 0.05) reduced in the DOC-saline-treated animals. No atheromata were observed in the animals consuming the regular diet, regardless of DOC-saline treatment. All of the animals fed the atherogenic diet showed extensive aortic atheromata. However, there was no difference in the lesion index between the animals with normal PRA levels (Group III) and those with suppressed PRA levels (Group IV). Likewise, microscopic evaluat...Continue Reading

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Citations

May 1, 1985·Circulation Research·A V ChobanianC Chan
Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGillC J Schwartz
Sep 1, 1990·The Journal of Primary Prevention·W C WorkP A Wyman
Jun 17, 2004·Journal of Basic and Clinical Physiology and Pharmacology·Mustafa Edremitlioğlu, Gülsen Oner

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