Renin-dependence of drinking induced by partial aortic obstruction in the dog

The Journal of Physiology
J T Fitzsimons, M J Moore-Gillon

Abstract

1. Inflation of a balloon implanted in the abdominal aorta above the level of the renal arteries was used to produce partial obstruction to aortic blood flow in trained, conscious mongrel dogs.2. Following inflation, heart rate and arterial blood pressure downstream from the point of inflation fell, whilst arterial blood pressure upstream from the point of inflation rose. Central venous pressure was unaltered.3. In sixteen out of eighteen experiments, balloon inflation led to drinking. Inflations maintained for 3 days led to a sustained increase in daily water intakes, but intakes of 0.9% NaCl were unaltered when both water and 0.9% NaCl were available to drink.4. There was a significant inverse correlation between the amount drunk in the first 60 min following balloon inflation and the ratio of the change in the arterial pressure upstream of the obstruction to the change in pressure downstream of the obstruction.5. In experiments where the inflation was maintained for 90 min, there was no further drinking between the 60th and 90th min. In experiments where the inflation was released after 60 min, there was another bout of drinking between the 60th and 90th min.6. Plasma renin activity and plasma renin concentration both rose f...Continue Reading

Citations

Jul 23, 1998·Physiological Reviews·J T Fitzsimons

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