Renin-expressing cells are associated with branching of the developing kidney vasculature.

Journal of the American Society of Nephrology : JASN
V ReddiR A Gomez

Abstract

To define the relationship between renal vascular development and renin distribution during kidney ontogeny, the complete renal arterial tree of Sprague Dawley rats during fetal (20 d) and postnatal (1 to 90 d) life was microdissected and immunostained for renin. A shift in renin distribution from interlobar and arcuate arteries in the fetus to the afferent arterioles in the adult was observed. In addition, seven types of renin distribution along the afferent arterioles were identified. In type I, renin was distributed continuously along the whole length of the afferent vessel. This pattern was most frequently observed in the fetus. In type II, renin extended upstream from the glomerulus but did not occupy the whole length of the arteriole. This type was relatively constant throughout postnatal life. In type III, renin was present as bands along the afferent vessel; it was most frequently observed in the fetal and early perinatal periods. In type IV, renin was restricted to the "classical" juxtaglomerular localization. It was the most frequent type observed in the adult rat. In type V, no renin was found in the arteriole. It was the second most frequent type observed in the adult rat. In addition, two "mixed" patterns, type III...Continue Reading

Citations

Apr 15, 1999·Current Opinion in Pediatrics·R A Gomez, V F Norwood
Apr 2, 2021·Circulation Research·Maria Luisa S Sequeira-Lopez, R Ariel Gomez
Mar 31, 2000·Nature Medicine·P Carmeliet
Jan 10, 2001·The Journal of Laboratory and Clinical Medicine·N ThanakornyothinB M Wilkes
Jan 24, 2003·The New England Journal of Medicine·Ja-Liang LinChun-Chen Yu
Feb 29, 2000·Journal of Hypertension·G Guron, P Friberg
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Maria Luisa S Sequeira Lopez, R Ariel Gomez
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul B Freeburg, Dale R Abrahamson
Feb 1, 2017·Hypertension·R Ariel Gomez
May 24, 2017·Hypertension·Masafumi OkaR Ariel Gómez
Mar 29, 2005·The Journal of Biological Chemistry·Li PanKenneth W Gross
Apr 21, 2007·Acta Physiologica Hungarica·L RosivallS MirzaHosseini
Apr 24, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sanjay JainHelen Liapis
Sep 28, 2007·Kidney International·A SauterC Wagner
Feb 12, 2008·Transplantation Proceedings·M R ArdalanM M Shoja
Jul 23, 1999·Renal Failure·R A GomezV F Norwood
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Björn NeubauerCharlotte Wagner
Sep 22, 2009·Transplantation Proceedings·M K TarzamniS Ghorashi
Oct 16, 2010·International Journal of Hypertension·Daniel Casellas
Jan 30, 2010·Mathematical Biosciences·Aurora Espinoza-ValdezFrancisco C Ordaz-Salazar
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
May 27, 2010·Current Opinion in Nephrology and Hypertension·Maria L S Sequeira Lopez, R Ariel Gomez
Aug 7, 2002·The American Journal of Pathology·Sébastien FuchsFlorence Pinet
Dec 8, 2004·The American Journal of Pathology·Jolanta E PiteraHai Tao Yuan
Jul 4, 2020·Clinical Science·Maria Florencia MartinezR Ariel Gomez

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