PMID: 7026517Jan 1, 1981Paper

Renin in the human kidney. Immunohistochemical localization

Histochemistry
M R Celio, T Inagami

Abstract

We have localized the enzyme renin (EC 3.4.99.19) in the normal adult human kidney by immunohistology. Serial paraffin sections of kidneys were incubated with renin antisera and then processed by the peroxidase-antiperoxidase method. Renin immunoreactivity was observed in the juxta-glomerular "epithelioid granular cells" (JEG-cells) in the wall of the afferent and rarely of the efferent vessel of the glomerulus. JEG-cells have long cytoplasmic processes penetrating between adjacent cells. This suggests a possible paracrine release of renin. Staining of various segments of the tubular system was shown to be artifactual. The kidney proteins recognized by our anti-human renin antisera had similar characteristics to renin when determined by a combination of gel-electrophoretic and immunologic techniques. Renin immunostaining in the juxtaglomerular apparatus of the human kidney is discrete and reflects the low amount of extractable renin.

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Citations

Jan 1, 1985·Anatomy and Embryology·M R CelioT Inagami
Dec 1, 1995·Histochemistry and Cell Biology·M HanssensF A Van Assche
Oct 1, 1996·The Journal of Urology·R KondaN Kimura
Feb 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A H FarajG B Lindop
Jan 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A H FarajS Coleman
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·J P CamilleriJ Bariety
Jun 1, 1993·Kidney International·Y KakinumaI Ichikawa
Jun 1, 1988·Kidney International·P C Graham, G B Lindop
Jun 19, 2013·The American Journal of Pathology·Jeffrey W PippinStuart J Shankland
Jan 31, 2018·Nature Reviews. Nephrology·R Ariel Gomez, Maria Luisa S Sequeira-Lopez
Jul 14, 2017·American Journal of Physiology. Renal Physiology·Alexis A GonzalezMinolfa C Prieto
Sep 1, 1991·Hypertension·T Inagami
Jan 24, 2007·Hypertension·Jean-Marc Lalouel, Andreas Rohrwasser
Sep 24, 2004·Physiological Reviews·Carsten A WagnerJohn P Geibel
May 27, 2004·American Journal of Physiology. Renal Physiology·Douglas R YingstRaymond R Mattingly
Feb 8, 2018·American Journal of Physiology. Renal Physiology·Hiroko HamataniStuart J Shankland
Sep 19, 2017·The American Journal of the Medical Sciences·Nicolás Salinas-ParraAlexis A Gonzalez
Apr 2, 2021·Circulation Research·Maria Luisa S Sequeira-Lopez, R Ariel Gomez
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Jean-Marc LalouelKenneth Ward

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