PMID: 7028611Nov 1, 1981Paper

Renin-like activity in the rat brain during the development of DOC-salt hypertension

Hypertension
N BassoA C Taquini

Abstract

Levels and distribution of an angiotensin-forming enzyme, active at the physiological pH (isorenin), were determined in the central nervous system of 24 rats treated with 25 mg/kg of deoxycorticosterone (DOC) subcutaneously, twice a week, plus saline to drink during 30 days and in 14 control animals. Different areas of the brain were excised and homogenized. Renin activity and concentration were determined by incubation of the supernatant of each homogenate at pH 7.2 alone and in the presence of an excess of renin substrate. The angiotensin generated was measured by radioimmunoassay. Concentration of the renin-like enzyme was significantly higher in the posterior hypophysis and in the brain stem of the experimental group; isorenin activity was higher in the hypothalamus, cerebral cortex, cerebellum, and brain stem of the DOC-salt-treated rats than in the control rats. Changes in the angiotensin-forming enzyme in the central nervous system of experimental animals, active at physiological pH, suggest that this isorenin system may play a role in the physiological response to DOC-salt in the rat. The significance of the brain isorenin system in the regulation of blood pressure requires further analysis.

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Citations

Jan 5, 2008·Heart Failure Reviews·Laurence BodineauCatherine Llorens-Cortes
Mar 8, 2005·Current Hypertension Reports·Annabelle Reaux-Le GoazigoCatherine Llorens-Cortes
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·J M Terris
May 1, 1992·Journal of Pharmacological and Toxicological Methods·J Schenk, J H McNeill
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claude Fournie-ZaluskiCatherine Llorens-Cortes
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·N BassoA C Taquini
Feb 1, 1989·Archives internationales de physiologie et de biochimie·N BassoA C Taquini
Jul 19, 2011·Progress in Neurobiology·Yannick Marc, Catherine Llorens-Cortes
Jan 16, 2008·Journal of Neuroendocrinology·C Llorens-Cortes, C Kordon
Jun 24, 2015·Journal of the American Society of Hypertension : JASH·Richard N Re
Oct 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephen F Rodrigues, Daniel Neil Granger
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·J A Weyhenmeyer, J M Meyer
Oct 1, 1988·The American Journal of Physiology·S H KimR L Malvin
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·D O GrinsponA C Taquini
Jul 28, 2013·The Journal of Biological Chemistry·Yang YangFang Li
Dec 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Qiannan GaoJun Cai
May 12, 2020·The Canadian Journal of Cardiology·Yannick MarcCatherine Llorens-Cortes

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