Renin mRNA concentration in rat hypothalamus is decreased by enalapril

Clinical and Experimental Pharmacology & Physiology
Y K LouB J Morris

Abstract

1. Renin mRNA is expressed in several extrarenal tissues, including brain. The aim of the present study was to quantify renin mRNA in the hypothalamus in response to a low NaCl diet and angiotensin converting enzyme inhibitor treatment, both of which are well-known stimuli of renin mRNA in kidney. 2. Groups of six Sprague-Dawley rats were given either a normal diet, low NaCl chow (0.04% NaCl), enalapril (0.25 mg/mL in drinking water), or low NaCl + enalapril, for 7 days. Renin mRNA in the hypothalamus was quantified by a competitive reverse transcriptase-polymerase chain reaction (RT-PCR) technique. 3. Renin mRNA concentration in the hypothalamus of rats receiving a normal diet was 52 +/- 3 S.E. fg/microgram total RNA. Low NaCl had no effect (57 +/- 7), whereas values were significantly lower in rats treated with enalapril, either given alone (38 +/- 2; P = 0.002) or combined with a low NaCl diet (33 +/- 4; P = 0.003). 4. In conclusion, we have quantified renin mRNA in the rat hypothalamus and shown that it can be suppressed significantly by enalapril. This response is opposite to that seen in the kidney after enalapril.

References

Mar 31, 1989·Biochemical and Biophysical Research Communications·M TadaK Murakami
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·H DeneJ P Rapp
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·H IwaoY Abe
Oct 1, 1988·Hypertension·S C MakridesH Gavras

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Citations

Jul 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tamás TerebessyIstván Mucsi
Dec 1, 1995·Clinical and Experimental Pharmacology & Physiology·B J Morris
Apr 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian J Morris
Jul 12, 2001·Experimental Biology and Medicine·A V FergusonK J Latchford

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