Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C beta II inhibition in a rat model of metabolic syndrome

Canadian Journal of Physiology and Pharmacology
Nallasamy PalanisamyC V Anuradha

Abstract

We studied whether substitution of soy protein for casein can improve insulin sensitivity, lower blood pressure (BP), and inhibit protein kinase C betaII (PKCbetaII) activation in kidney in an acquired model of metabolic syndrome. Adult male rats were fed 4 different diets: (i) starch (60%) and casein (20%) (CCD), (ii) fructose (60%) and casein (20%) (FCD), (iii) fructose (60%) and soy protein (20%) (FSD), and (iv) starch (60%) and soy protein (20%) (CSD). Renal function parameters, BP, pressor mechanisms, PKCbetaII expression, oxidative stress, and renal histology were evaluated after 60 days. FCD rats displayed insulin resistance and significant changes in body weight, kidney weight, urine volume, plasma and urine electrolytes accompanied by significant changes in renal function parameters compared with CCD rats. Elevated BP, plasma angiotensin-converting enzyme (ACE) activity, renal oxidative stress, and reduced nitrite (NO) and kallikrein activity were observed. Western blot analysis revealed enhanced renal expression of membrane-associated PKCbetaII in the FCD group. Histology showed fatty infiltration and thickening of glomeruli while urinary protein profile revealed a 5-fold increase in albumin. Substitution of soy prote...Continue Reading

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Citations

May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nallasamy Palanisamy, Carani Venkataraman Anuradha
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Sunil K Panchal, Lindsay Brown
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May 7, 2016·World Journal of Nephrology·Nancy J McGrawAlan R Parrish
Oct 14, 2011·Nutrition Research and Practice·Ha-Neul ChoiJung-In Kim

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