Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway

Evidence-based Complementary and Alternative Medicine : ECAM
Xue YangShaoping Deng

Abstract

The aim of the study was to investigate the protective effect of Danhong injection (DHI) on diabetic kidney disease and explore the potential mechanisms. Diabetic kidney disease was induced by unilateral nephrectomy, high-fat diet, and streptozotocin. After DHI administration, the renal function deterioration, 24-hour total urine protein excretion, and elevated serum lipid levels were reversed to some extent, and the renal pathological damage was also ameliorated. The KEGG pathway enrichment analysis demonstrated that the PPARγ signal pathway was significantly upregulated in DH group. And the increased expressions of PPARγ and UCP-1 were confirmed by immunohistochemistry, whereas the p38MAPK was significantly decreased. These data show that DHI could delay the progress of DKD, and the effect might be achieved in part by activating the PPARγ signaling pathway.

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Citations

Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shisheng HanYi Wang
Jul 23, 2020·Journal of Diabetes Research·Dorin DragoșDorin Ionescu

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Methods Mentioned

BETA
Feature
chip
environmental stresses

Software Mentioned

Agilent Feature Extraction
SPSS
Agilent GeneSpring GX

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